Compositions and methods for treating psoriasis by ganoderma lucidum (Reishi) polysaccharides

• US 20090060940A1
• Filed: 08/29/2008
• Published: 03/05/2009
• Est. Priority Date: 08/30/2007
• Status: Active Grant

• Current Assignee: Academia Sinica (Government of The Republic of China), Wyntek Corporation
• Original Assignee: Academia Sinica (Government of The Republic of China), Wyntek Corporation
• Inventors: Wong, Chi-Huey, Fan, Eugene, Tu, Tseng-Rong, Su, Sung-Hsieh, Li, Chia-Feng
• Granted Patent: US 7,947,283 B2
• Time in Patent Office: Days
• US Class Current: 424/195.150
• CPC Class Codes: A61K 36/074 Ganoderma
• CPC Class Codes: A61P 17/06 Antipsoriatics

Abstract

A method for treating psoriasis by providing a pharmaceutical composition containing at least Ganoderma lucidum extract and administering a therapeutically effective amount of the composition to a patient in need thereof. Also disclosed is a method for treating psoriasis by first purifying Ganoderma lucidum extract into at least one fraction, then providing a pharmaceutical composition comprising at least one of the Ganoderma lucidum fractions, and administering a therapeutically effective amount of the composition to a patient in need thereof. A method for alleviating symptoms of psoriasis is disclosed. The symptoms of psoriasis are alleviated by providing a pharmaceutical composition containing at least Ganoderma lucidum extract and administering an amount of the composition effective to increase at least one of an IL-10 and IL-1Ra expression, whereby the symptoms of psoriasis are ameliorated.

Claims

1. A method for treating psoriasis, the method comprising:

providing a pharmaceutical composition containing at least Ganoderma lucidum extract; and

administering a therapeutically effective amount of the composition to a patient in need thereof.

2. The method of claim 1 wherein said composition is administered intravenously, intradermally, subcutaneously, orally, transdermally, transmucosally, or rectally.

3. The method of claim 1 wherein said composition is formulated as a cream, gel, salve, ointment, solution, tablet, capsule, spray, or patch.

4. The method of claim 1 wherein said Ganoderma lucidum extract increases at least one of an IL-10 and IL-1Ra expression in the patient.

5. A method for treating psoriasis comprising:

purifying Ganoderma lucidum extract into at least one fraction;

providing a pharmaceutical composition comprising at least one of the Ganoderma lucidum fractions; and

administering a therapeutically effective amount of the composition to a patient in need thereof.

6. The method of claim 5 wherein said composition is administered intravenously, intradermally, subcutaneously, orally, transdermally, transmucosally, or rectally.

7. The method of claim 5 wherein said composition is formulated as a cream, gel, salve, ointment, solution, tablet, capsule, spray, or patch.

8. The method of claim 5 wherein said fraction comprises at least one fucose-containing glycoprotein.

9. The method of claim 5 wherein said fraction increases at least one of an IL-10 and IL-1Ra expression in the patient.

10. A pharmaceutical composition for treating psoriasis comprising a Ganoderma lucidum extract.

11. The method of claim 10 wherein said composition is formulated as a cream, gel, salve, ointment, solution, tablet, capsule, spray, or patch.

12. The composition of claim 10 wherein said Ganoderma lucidum extract increases at least one of an IL-10 and IL-1Ra expression in the patient.

13. A method for alleviating symptoms of psoriasis, the method comprising:

providing a pharmaceutical composition containing at least Ganoderma lucidum extract; and

administering an amount of the composition effective to increase at least one of an IL-10 and IL-1Ra expression, whereby the symptoms of psoriasis are ameliorated.