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RESORBABLE BARRIER MICRO-MEMBRANES FOR ATTENUATION OF SCAR TISSUE DURING HEALING

  • US 20090060978A1
  • Filed: 08/27/2008
  • Published: 03/05/2009
  • Est. Priority Date: 08/27/2007
  • Status: Abandoned Application
First Claim
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1. A resorbable micro-membrane system for attenuating or preventing a formation of post-surgical scar tissue between a healing post-surgical site and adjacent surrounding tissue following an in vivo surgical procedure on the post-surgical site, the system having a pre-implant configuration immediately before the system is formed between the post-surgical site and the adjacent surrounding tissue, the system comprising:

  • a substantially planar membrane of resorbable polymer base material having a first substantially-smooth side and a second substantially-smooth side, the substantially planar membrane of resorbable polymer base material comprising a single layer of resorbable polymer base material between the first substantially-smooth side and the second substantially-smooth side, the single layer of resorbable polymer base material having a substantially uniform composition;

    wherein a thickness of the single layer of resorbable polymer base material, measured between the first substantially-smooth side and the second substantially-smooth side, is between about 0.01 mm and about 0.300 mm;

    wherein the single layer of resorbable polymer base material is non-porous; and

    wherein the single layer of resorbable polymer base material is adapted to maintain a smooth-surfaced barrier between the healing post-surgical site and the adjacent surrounding tissue for a relatively extended period of time sufficient to attenuate or eliminate any formation of scar tissue between the post-surgical site and the adjacent surrounding tissue.wherein the single layer of resorbable polymer base material comprises one or more of (a) a dual block copolymer including a first hydrophobic block of one or more of a lactide and a glycolide and a second hydrophilic block of a polyethylene glycol (PEG), and (b) a tri block copolymer including a first hydrophobic block of one or more of a lactide and a glycolide, a second hydrophilic block of a polyethylene glycol (PEG), and a third hydrophobic block of one or more of a lactide and a glycolide, wherein the third hydrophobic block is either the same or different from the first hydrophobic block.

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