Contact lens based bioactive agent delivery system

• US 20090060981A1
• Filed: 09/04/2007
• Published: 03/05/2009
• Est. Priority Date: 09/04/2007
• Status: Active Grant

• Current Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Original Assignee: University of Florida Research Foundation, Incorporated (State University System of Florida)
• Inventors: Chauhan, Anuj
• Granted Patent: US 8,075,909 B2
• Time in Patent Office: Days
• US Class Current: 424/429
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

A bioactive agent delivery system comprising an optically transparent contact lens having dispersed therein (1) an ophthalmically bioactive agent capable of diffusion through the contact lens and into the post-lens tear film when placed on the eye and (2) associated with the bioactive agent, an ophthalmically compatible polymeric surfactant in an amount sufficient to slow the rate of migration of the bioactive agent through the contact lens.

Claims

1. A bioactive agent delivery system comprising a substantially optically transparent contact lens having dispersed therein (1) an ophthalmically bioactive agent, said agent being capable of diffusion through said contact lens and into the post-lens tear film when said contact lens is placed on the eye and (2) associated with said bioactive agent, at least one ophthalmically compatible polymeric surfactant, said surfactant being present in an amount sufficient to attenuate the rate of migration of said bioactive agent through said contact lens.

2. A bioactive agent delivery system of claim 1 wherein said polymeric surfactant comprises a block copolymer having a hydrophobic segment and a hydrophilic segment

3. A bioactive agent delivery system of claim 2 wherein said bioactive agent is hydrophobic and is associated with the hydrophobic segment of said surfactant.

4. A bioactive agent delivery system of claim 1 wherein said contact lens comprises a polymer formed from a reaction mixture comprising at least one hydrophilic monomer.

5. A bioactive agent delivery system of claim 4 wherein said hydrophilic monomer is an unsaturated carboxylic acid;

acrylic substituted alcohol;

vinyl lactam or acrylamide.

6. A bioactive agent delivery system of claim 5 wherein said hydrophilic monomer is selected from the group consisting of methacrylic or acrylic acid, 2-hydroxyethylmethacrylate, 2-hydroxyethylacrylate, N-vinyl pyrrolidone, methacrylamide, N-vinyl-N-methacetamied, N,N-dimethylacrylamide, and mixtures thereof.

7. A bioactive agent delivery system of claim 1 wherein said bioactive agent is hydrophilic and is associated with the hydrophilic segment of said surfactant.

8. A bioactive agent delivery system of claim 1 wherein said contact lens comprises a hydrophobic material.

9. A bioactive agent delivery system of claim 8 wherein said hydrophobic material is selected from the group consisting of a silicone, silicone containing prepolymers and macromers, polydimethylsiloxane, pentamethyldisiloxanyl methylmethacrylate, tris(trimethylsiloxy)methacryloxy propylsilane, methyldi(trimethylsiloxy)methacryloxymethyl silane, monomethacryloxypropyl terminated mono-n-butyl terminated polydimethylsiloxane, mono-(3-methacryloxy-2-hydroxypropyloxy)propyl terminated, mono-butyl terminated polydimethylsiloxane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxanes, 3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, methyl methacrylate, ethylene glycol di-methacrylate, and mixtures thereof.

10. A method of manufacturing a bioactive agent delivery system of claim 1 comprising providing a monomer mixture comprising a lens-forming monomer, the surfactant and the bioactive agent and polymerizing said monomer mixture.

11. A method of manufacturing a bioactive agent delivery system of claim 1 without introducing a bioactive agent before polymerization.

12. A method of loading drug into the system of claim 11 by soaking the device in at least one drug solution.

13. A method of loading drug into the system of claim 11 by packaging the device in drug solutions.

14. A method of administering an ophthalmically bioactive agent to the eye comprising contacting the eye with the bioactive agent delivery system of claim 1.