METHODS AND SYSTEMS OF DELIVERING A PROBABILITY OF A MEDICAL CONDITION
First Claim
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1. A method of delivering a probability that a subject has a medical condition to a user comprising:
- a) calculating a posterior probability that a subject has a medical condition, wherein said subject has a biomarker trend, wherein said trend is formed by values corresponding to a biomarker for said medical condition obtained at least two different times from said subject, by relating;
i) a probability of observing said biomarker trend for an individual with said medical condition;
ii) a probability of observing said biomarker trend for an individual without said medical condition; and
iii) a prior probability that said subject has said medical condition; and
b) delivering said posterior probability to a user with an output device.
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Abstract
Methods and systems for delivering a probability that a subject has a medical condition are disclosed herein. The methods comprise calculating the probability of a medical condition using biomarker values and the rate of change of the biomarker values over time. In most embodiments, the methods comprise relations and calculations that require computer systems to execute the methods of the invention. Systems of the invention may include computer systems, as well as medical systems, such as biomarker assays and courses of medical action.
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Citations
54 Claims
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1. A method of delivering a probability that a subject has a medical condition to a user comprising:
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a) calculating a posterior probability that a subject has a medical condition, wherein said subject has a biomarker trend, wherein said trend is formed by values corresponding to a biomarker for said medical condition obtained at least two different times from said subject, by relating; i) a probability of observing said biomarker trend for an individual with said medical condition; ii) a probability of observing said biomarker trend for an individual without said medical condition; and iii) a prior probability that said subject has said medical condition; and b) delivering said posterior probability to a user with an output device. - View Dependent Claims (2, 3, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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4. A method of delivering a probability that a subject has a medical condition to a user comprising:
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a) calculating a posterior probability that a subject has a medical condition, wherein said subject has a biomarker value for said medical condition, by relating; i) a probability of observing said biomarker value for an individual with said medical condition; ii) a probability of observing said biomarker value for an individual without said medical condition; and iii) a prior probability that said subject has said medical condition; and b) delivering said posterior probability to a user with an output device. - View Dependent Claims (5, 6)
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7. A method of delivering a probability that a subject has a medical condition to a user comprising:
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a) calculating a posterior probability that a subject has a medical condition, wherein said subject has a first biomarker value and a second biomarker value for said medical condition, wherein said second biomarker value is obtained after said first biomarker, by relating; i) a probability of observing said second biomarker value for an individual with said medical condition; ii) a probability of observing said second biomarker value for an individual without said medical condition; iii) a probability of observing a biomarker rate of change for an individual with said medical condition, wherein said biomarker rate of change is the difference of biomarker values over time; iv) a probability of observing said biomarker rate of change for an individual without said medical condition; and v) a prior probability that said subject has said medical condition; and b) delivering said posterior probability to a user with an output device. - View Dependent Claims (8, 9, 10, 11)
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41. A medical information system for delivering a probability of a medical condition of a subject to a user comprising:
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a) an input device for obtaining biomarker values corresponding to a biomarker for a medical condition at least two different times from said subject, wherein said biomarker values form a biomarker trend; b) a processor in communication with said input device, wherein said processor uses said biomarker trend to calculate a posterior probability of said subject having said medical condition; c) a storage unit in communication with at least one of the input device and the processor, wherein said storage unit comprises at least one database comprising said biomarker values, said posterior probability, or a prior probability of said subject having said medical condition; and d) an output device in communication with at least one of said processor and said storage unit, wherein said output device transmits said posterior probability to a user. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 52)
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51. The system of claim 51, wherein said medical test is a PSA assay.
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53. The method of claim 53, wherein the medical treatment is selected from a group consisting of the following:
- a pharmaceutical, surgery, organ resection, and radiation therapy.
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54. A method of delivering a probability of a medical condition of a subject to a user comprising:
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a) collecting biomarker values from a subject corresponding to a biomarker for a medical condition at least two different times, wherein the biomarker values at the at least two different times form a biomarker trend; b) exporting said biomarker trend for analysis, wherein said analysis comprises; calculating a posterior probability that a subject has a medical condition by relating;
i) a probability of observing said biomarker trend for an individual with said medical condition;
ii) a probability of observing said biomarker trend for an individual without said medical condition; and
iii) a prior probability that said subject has said medical condition;c) importing the results of said analysis to an output device; and d) delivering said posterior probability to a user with said output device.
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Specification