Implantable Systemic Blood Pressure Measurement Systems and Methods
First Claim
1. For use with an implantable system, a method for monitoring a patient'"'"'s arterial blood pressure, the method comprising:
- (a) using implanted electrodes to obtain a first signal indicative of electrical activity of the patient'"'"'s heart;
(b) using an implanted sensor to obtain a second signal indicative of mechanical activity of the patient'"'"'s heart;
(c) detecting a ventricular depolarization and a ventricular repolarization in a portion of the first signal corresponding to a cardiac cycle;
(d) detecting a maximum peak amplitude in a portion of the second signal corresponding to the same cardiac cycle;
(e) determining a time t1 from the detected ventricular depolarization to the detected maximum peak amplitude in the second signal;
(f) determining a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal;
(g) determining a peak pulse arrival time (PPAT) based on times t1 and t2; and
(h) determining a value indicative of systolic pressure (SP) based on the PPAT.
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Accused Products
Abstract
Implantable systems, and methods for use therewith, for monitoring arterial blood pressure on a chronic basis are provided herein. A first signal indicative of electrical activity of a patient'"'"'s heart, and a second signal indicative of mechanical activity of the patient'"'"'s heart, are obtained using implanted electrodes and an implanted sensor. By measuring the times between various features of the first signal relative to features of the second signal, values indicative of systolic pressure and diastolic pressure can be determined. In specific embodiments, such features are used to determine a peak pulse arrival time (PPAT), which is used to determine the value indicative of systolic pressure. Additionally, a peak-to-peak amplitude at the maximum peak of the second signal, and the value indicative of systolic pressure, can be used to determine the value indicative of diastolic pressure.
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Citations
37 Claims
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1. For use with an implantable system, a method for monitoring a patient'"'"'s arterial blood pressure, the method comprising:
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(a) using implanted electrodes to obtain a first signal indicative of electrical activity of the patient'"'"'s heart; (b) using an implanted sensor to obtain a second signal indicative of mechanical activity of the patient'"'"'s heart; (c) detecting a ventricular depolarization and a ventricular repolarization in a portion of the first signal corresponding to a cardiac cycle; (d) detecting a maximum peak amplitude in a portion of the second signal corresponding to the same cardiac cycle; (e) determining a time t1 from the detected ventricular depolarization to the detected maximum peak amplitude in the second signal; (f) determining a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal; (g) determining a peak pulse arrival time (PPAT) based on times t1 and t2; and (h) determining a value indicative of systolic pressure (SP) based on the PPAT. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An implantable system configured to monitor a patient'"'"'s arterial blood pressure, comprising:
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a first detector configured to detect ventricular depolarizations and ventricular repolarizations in cardiac cycles represented in a first signal that is indicative of electrical activity of a patient'"'"'s heart; a second detector configured to detect maximum peak amplitudes in cardiac cycles represented in a second signal indicative of mechanical activity of the patient'"'"' heart; an arterial blood pressure monitor configured to determine a time t1 from a detected ventricular depolarization to a detected maximum peak amplitude in the second signal; determine a time t2 from the detected ventricular repolarization to the detected maximum peak amplitude in the second signal; determine a peak pulse arrival time (PPAT) based on times t1 and t2; and determine a value indicative of systolic pressure (SP) based on the PPAT. - View Dependent Claims (22, 23, 24, 25, 26)
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27. For use with an implantable system, a method for monitoring a patient'"'"'s arterial blood pressure, the method comprising:
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(a) using implanted electrodes to obtain a first signal indicative of electrical activity of the patient'"'"'s heart; (b) using an implanted sensor to obtain a second signal indicative of mechanical activity of the patient'"'"'s heart; (c) detecting a ventricular depolarization in a portion of the first signal corresponding to a cardiac cycle; (d) detecting a maximum peak amplitude in a portion of the second signal corresponding to the same cardiac cycle; (e) determining a pulse arrival time (PAT) by determining a time t1 from detection of the ventricular depolarization to the detection of the maximum peak amplitude in the second signal; and (f) determining a value indicative of systolic pressure (SP) based on the PAT. - View Dependent Claims (28, 29, 30, 31)
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32. An implantable system configured to monitor a patient'"'"'s arterial blood pressure, comprising:
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a first detector configured to detect ventricular depolarizations in cardiac cycles represented in a first signal that is indicative of electrical activity of a patient'"'"'s heart; a second detector configured to detect maximum peak amplitudes in cardiac cycles represented in a second signal indicative of mechanical activity of the patient'"'"' heart; an arterial blood pressure monitor configured to determine a time t1 from a detected ventricular depolarization to a detected maximum peak amplitude in the second signal; determine a pulse arrival time (PAT) based on the time t1; and determine a value indicative of systolic pressure (SP) based on the PAT. - View Dependent Claims (33, 34, 35, 36, 37)
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Specification