ANALYTICAL INSTRUMENT
First Claim
1. An analytical instrument, comprising:
- an ionization means for ionizing a mixture of a target sample and a specific compound added thereto;
a means for performing mass analysis on resulting ions; and
a data processor that determines the concentration of a target compound contained in the target sample,wherein the data processor includes a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, and the data processor calculates, by using the database, the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means.
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Abstract
The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
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Citations
17 Claims
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1. An analytical instrument, comprising:
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an ionization means for ionizing a mixture of a target sample and a specific compound added thereto; a means for performing mass analysis on resulting ions; and a data processor that determines the concentration of a target compound contained in the target sample, wherein the data processor includes a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, and the data processor calculates, by using the database, the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An analysis method for determining the concentration of a target compound contained in a target sample, comprising the steps of:
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ionizing, by an ionization unit, a mixture of a target sample and a specific compound added thereto; making measurements on resulting ions, by a mass analyzer; and calculating, by a data processor using a database, the concentration of the target compound from a signal derived from the target compound and a signal derived form the addition compound, which signals are measured by the mass analyzer, the database storing dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound. - View Dependent Claims (13, 14)
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15. A calibration method for sensitivity changes in a mass spectrometer, comprising the steps of:
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introducing a compound of known concentration into an ionization unit; measuring ion intensity derived from the ionized compound, by a mass analyzer; and performing, by a data processor using a database, a comparison with the sensitivity of the compound observed when the concentration of the matrix component is 0, the database storing dependence of signal intensity on the concentration of a matrix component for the compound. - View Dependent Claims (16, 17)
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Specification