Treatment And Prophylaxis With 4-1BB-Binding Agents
First Claim
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1. A method for depleting double negative T cells in a subject, said method comprising:
- (a) identifying a subject as having, or at risk of having, an autoimmune disease, a lymphoproliferative disease, or an allergy; and
(b) administering to said subject an effective amount of a 4-1BB agonist.
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Abstract
Materials and Methods for using 4-1BB agonists to treat or prevent autoimmune disorders, lymphoproliferative diseases, and allergies are provided.
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Citations
34 Claims
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1. A method for depleting double negative T cells in a subject, said method comprising:
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(a) identifying a subject as having, or at risk of having, an autoimmune disease, a lymphoproliferative disease, or an allergy; and (b) administering to said subject an effective amount of a 4-1BB agonist. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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- 18. A method for inducing death of a double negative T cell, said method comprising contacting said double negative T cell with an effective amount of a 4-1BB agonist.
Specification