Delivery of pharmaceutical agents via the human insulin receptor
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Abstract
A humanized murine antibody is provided that binds to the human insulin receptor (HIR). The humanized murine antibody is suitable for use as a Trojan horse to deliver pharmaceutical agents to human organs and tissue that express the HIR. The humanized murine antibody is especially well suited for delivering neuropharmaceutical agents from the blood stream to the brain across the blood brain barrier (BBB). The humanized murine antibody may be genetically fused to the pharmaceutical agent or it may be linked to the pharmaceutical agent using an avidin-biotin conjugation system.
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Citations
27 Claims
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1-17. -17. (canceled)
- 18. A method for increasing the ability of a neuropharmaceutical agent to cross the human blood brain barrier, the method comprising linking said neuropharmaceutical agent to a humanized antibody that binds to the human insulin receptor.
- 21. A method for targeting a pharmaceutical agent to the human insulin receptor in vivo, the method comprising linking said pharmaceutical agent to a humanized antibody that binds to the human insulin receptor.
- 24. A method for intravenously administering a pharmaceutical agent to a human patient, said method comprising injecting a pharmaceutical preparation comprising the pharmaceutical agent linked to a humanized monoclonal antibody that binds the human insulin receptor into the blood stream of said human patient.
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