MEASUREMENT APPARATUS

• US 20090069676A1
• Filed: 09/12/2008
• Published: 03/12/2009
• Est. Priority Date: 09/12/2007
• Status: Abandoned Application

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Nishihara, Hiroshi
• Application Number:
  US12/209,556
• Publication Number:
  US 20090069676A1
• Time in Patent Office: Days
• US Class Current: 600/437
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A measurement apparatus is configured to measure a spectroscopic characteristic of a specimen. The measurement apparatus includes a light source configured to generate light to be irradiated onto the specimen, an ultrasound generating unit configured to generate an ultrasound, an ultrasound focusing unit configured to focus the ultrasound generated by the ultrasound generating unit on a measurement area of the specimen, a light detecting unit configured to detect modulated light derived from the light by an acousto optical effect on the measurement area of the specimen, and a control unit configured to control, based on an output of the light detecting unit, at least one of an intensity and a frequency of the ultrasound generated by the ultrasound generating unit, an ultrasound focusing size made by the ultrasound focusing unit, and an intensity of the light generated from the light source.

Claims

1. A measurement apparatus configured to measure a spectroscopic characteristic of a specimen by acousto-optical tomography, the measurement apparatus comprising:

a light source configured to provide light to be irradiated onto the specimen;

an ultrasound generating unit configured to generate ultrasound;

an ultrasound focusing unit configured to focus the ultrasound generated by the ultrasound generating unit on a measurement area of the specimen;

a light detecting unit configured to detect light modulated by the acousto-optical effect on the measurement area of the specimen; and

a control unit operable to control at least one of the parameter;

the intensity of the ultrasound generated by the ultrasound generating unit, the frequency of the ultrasound generated by the ultrasound generating unit, the ultrasound focusing size made by the ultrasound focusing unit, and the intensity of the light from the light source, based on an output of the light detecting unit.

2. A measurement apparatus according to claim 1, further comprising a signal analyzing unit configured to compare a signal level of the modulated light with a noise level of the light detecting unit and to communicate the result of the comparison to the control unit.

3. A measurement apparatus according to claim 2, wherein the signal analyzing unit generates coordinate data of a focusing position and distribution data of a spectroscopic characteristic in the specimen from a light signal of the modulated light.

4. A measurement apparatus according to claim 1, wherein the control unit is configured to scan a focusing position of the ultrasound focused by the ultrasound focusing unit, and repeats the measurement at a first scanning position by increasing at least one of the intensity and frequency of the ultrasound, the focusing size of the ultrasound, and the intensity of the light from an initial value, when the signal to noise ratio of the modulated light is equal to or smaller than a threshold value at a first focusing position of the ultrasound, and provides a measurement at a second focusing position different from the first focusing position by resetting the at least one controller parameter(s) to the initial value which has been increased for the first focusing position.

5. A measurement apparatus according to claim 1, further comprising:

a mode selecting switch adapted to allow a user to select either a rough scan mode or a fine scan mode; and

a control unit configured to set an ultrasound focusing size to be smaller in the fine scan mode than in the rough scan mode.

6. A measurement apparatus according to claim 5, further comprising a measurement area setting unit configured to set a measurement area of the measurement site in the specimen.

7. A measurement apparatus according to claim 5, further comprising a focusing size setting device configured to set the ultrasound focusing position made by the ultrasound focusing unit.

8. A measurement apparatus according to claim 1, further comprising an ultrasound detecting unit which detects the ultrasound, wherein the control unit controls the intensity of the ultrasound generated by the ultrasound generating unit based on a detection result of the ultrasound detecting unit.

9. A measurement apparatus according to claim 8, wherein the ultrasound generating unit and the ultrasound detecting unit constitutes a single ultrasound transducer.

10. A method of measuring a spectroscopic characteristic of a specimen by acousto-optical tomography, the method comprising:

irradiating the specimen with light;

focusing ultrasound on a measurement area of the specimen;

detecting light modulated by the acousto-optical effect on the measurement area of the specimen,

characterized in that the method further comprises;

controlling at least one of the parameters;

the intensity of the ultrasound generated by the ultrasound source;

the frequency of the ultrasound generated by the ultrasound source;

the ultrasound focusing size (D1, D2) made by the ultrasound focusing unit; and

the intensity of the light from the light source, based on the detected modulated light.