Method of measuring instantaneous arterial blood pressure and compliance and device thereof

• US 20090069699A1
• Filed: 02/19/2008
• Published: 03/12/2009
• Est. Priority Date: 09/12/2007
• Status: Active Grant

• Current Assignee: E-Med Biotech, Inc.
• Original Assignee: E-Med Biotech, Inc.
• Inventors: Lin, Albert Chin-Yuh
• Granted Patent: US 7,662,102 B2
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure

Abstract

A method of measuring the instantaneous arterial blood pressure and compliance and the device thereof are disclosed. The method identifies a critical depth under the skin. At this critical position, the arterial mean blood pressure is equivalent to the mean blood pressure obtained on the skin. The variation in the arterial mean blood pressure is tracked and controlled to maintain the equivalence between the mean blood pressure measured on the skin and the arterial mean blood pressure. In this case, the compliance of the muscle tissues remains invariant. Therefore, the variation measured on the skin is simply the behavior of the blood vessel. Using the skin-artery correlation, the invention can obtain the instantaneous blood pressure after some computation and the dynamic compliance at the critical position.

Claims

1. A method for measuring the arterial instantaneous blood pressure and compliance, comprising:

a searching step;

finding the critical depth λ

_s when P_s= P_b and determining P_s and λ

_s using an actuator to impose a pressure on the skin, a pressure sensor to measure a skin mean blood pressure P_s, and a displacement sensor to detect the depth λ

_s under the pressure, then using the pressure sensor to measure the peak-to-peak pressure value, where the above-mentioned procedure is repeated until the maximum peak-to-peak value is reached, with the corresponding depth being the critical depth λ

_s and the mean blood pressure measured at the skin being equal to the arterial mean blood pressure P_b;

wherein P_s is the mean blood pressure measured at the skin, P_b is the arterial mean blood pressure, and λ

_s is the critical depth of the skin;

a controlling step;

using the pressure sensor to monitor the blood pressure change Δ

P_s transmitted from the artery to the skin when the arterial blood pressure changes by Δ

P_b at the critical depth λ

_s, using the actuator to change the depressed depth of the skin for generating the corresponding displacement change Δ

λ

_s so that the blood pressure change at the skin Δ

P_s approaches zero, in which case the muscle tissue compliance remain invariant, the tissue stiffness K_t being equal to the tissue impedance Z_t and thus making the mean blood pressure at the skin P_s and the arterial mean blood pressure P_b remain equivalent, where the displacement change Δ

λ

_s of the actuator detected by the displacement sensor is the variation in the arterial blood vessel diameter;

wherein Δ

P_b is the difference between the arterial blood pressure and the mean blood pressure, Δ

λ

_s is the displacement change from the critical depth λ

_s for the arterial mean blood pressure change of Δ

P_b;

an identifying step;

simulating the artery vessel as a second-order system with mass, damping, and stiffness and performing system identification to obtain blood vessel parameters M_v, D_v, and K_v as well as the artery impedance Z_v;

an estimating step;

transmitting the detected signal to a controlling unit for computations, using the mean blood pressure at the skin P_s, the artery impedance Z_v, and the arterial blood vessel diameter change Δ

λ

_s to estimate the arterial instantaneous blood pressure {circumflex over (P)}_b, and using the arterial instantaneous blood pressure {circumflex over (P)}_b and the diameter displacement change Δ

λ

_v to make a plot of the arterial dynamic compliance at the critical position.

2. The method of claim 1, wherein the arterial blood vessel diameter change is given by

$\Delta$





λ

s = - 1 / Z v 

Δ





P b = Δ





λ

v .

3. The method of claim 1, wherein the arterial instantaneous blood pressure is estimated using the formula

{circumflex over (P)}_b= P_b+Δ

P_b= P_s−

Z_vΔ

λ

_s.

4. The method of claim 1, wherein the arterial dynamic compliance is computed using

$\begin{array}{c}C=[\end{array}$

( Δ

λ

s ) / 

P ^ b ] 

| P _ b = P _ s .

5. The method of claim 1, wherein when the arterial mean blood pressure P_b changes by Δ

P_b so that the diameter of the arterial blood vessel changes, the actuator urges in the direction opposite to the upper edge of the blood vessel for tracking the mean blood pressure change Δ

P_b, enabling the detection head at the skin to reach a new critical depth and making the new mean blood pressure P_s and the new arterial mean blood pressure P_b equal to each other again.

6. The method of claim 5, wherein the actuator increases the depression depth of the skin when the arterial mean blood pressure P_b increases so that the blood vessel inflates.

7. The method of claim 5, wherein the actuator reduces the depression depth of the skin when the arterial mean blood pressure P_b reduces so that the blood vessel contracts.

8. A device for measuring the arterial instantaneous blood pressure according to the method of claim 1, comprising:

a detection head disposed on a skin surface, including at least an actuator, a displacement sensor, and a pressure sensor;

a controlling unit, electrically coupled with the actuator, the displacement sensor, and the pressure sensor for analyzing and processing signals;

wherein the actuator is controlled by the controlling unit to depress the skin surface;

the displacement sensor is used to detect the depression depth of the actuator and send the displacement signal to the controlling unit for signal processing; and

the pressure sensor is used to detect the pressure signal at the skin surface and send the pressure signal to the controlling unit for signal processing.