Method and Apparatus fo Computer Modeling Diabetes

• US 20090070088A1
• Filed: 03/31/2008
• Published: 03/12/2009
• Est. Priority Date: 05/02/2001
• Status: Abandoned Application

• Current Assignee: Entelos, Inc. (SilkRoad Inc.)
• Original Assignee: Entelos, Inc. (SilkRoad Inc.)
• Inventors: Hall, Kevin, Trimmer, Jeff, Siler, Scott, Brahznik, Paul, Polidori, Dave
• Application Number:
  US12/060,142
• Publication Number:
  US 20090070088A1
• Time in Patent Office: Days
• US Class Current: 703/11
• CPC Class Codes: A61P 7/12 Antidiuretics, e.g. drugs for diabetes insipidus ADH A61P5/10
• CPC Class Codes: G16B 5/00 ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16B 5/10 Boolean models
• CPC Class Codes: G16B 5/30 Dynamic-time models
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control mechanisms directing, for example, fat metabolism, protein metabolism and/or carbohydrate metabolism. In one embodiment, for example, the model can account for the interconversion between macronutrients, as well as their digestion, absorption, storage, mobilization, and adaptive utilization, as well as the endocrine control of these processes. In this embodiment, the model can simulate, for example, a heterogeneous group of diabetes related disorders, from insulin resistant to severe diabetic, and can predict the likely effects of therapeutic interventions.

Claims

1-6. -6. (canceled)

7. A computer model of a disease state of diabetes, comprising:

a computer-readable memory storing;

instructions defining a set of biological processes related to the disease state of diabetes, at least two biological processes from the set of biological processes being associated with a set of mathematical relationships related to interactions among biological variables associated with the biological processes, the instructions defining a simulation of glucose metabolism in the context of multiple macronutrient metabolism; and

a processor coupled to the computer-readable memory, the processor configured to execute the instructions.

8. The computer model of claim 7, wherein, upon execution of the instruction, the processor is configured to produce a simulated biological attribute for the disease state of diabetes, the simulated biological attribute is substantially consistent with at least one biological attribute associated with a reference pattern of diabetes.

9. The computer model of claim 7, wherein the instructions further define a set of defects associated with diabetes, the set of defects including a first defect and a second defect, the first defect is a modification of a first biological process from the set of biological processes, the first biological process is related to biological attributes of diabetes in a reference pattern of diabetes, the second defect is a modification of the first biological process or a second biological process from the set of biological processes, the second biological process is related to biological attributes of diabetes in the reference pattern of diabetes.

10. A computer executable software code, comprising:

code to define a normal biological state through a set of biological processes, each biological process from the set of biological processes having its own associated parameter set, the set of biological processes being related to glucose metabolism in the context of multiple macronutrient metabolism;

code to provide a plurality of predefined defect indicators, each predefined defect indicator from the plurality of predefined defect indicators being uniquely associated with a defect from a plurality of defects associated with a disease state of diabetes, each defect from the plurality of defects being associated with at least one biological process from the set of biological processes; and

code to receive a user-specified identification oaf first defect indicator from the plurality of predefined defect indicators, a first defect from the plurality of defects being associated with the first defect indicator, the parameter set associated with each biological processes that is associated with the first defect being changed based on the user-specified identification.

11. The computer executable software code of claim 10, further comprising:

code to determine at least one simulated biological attribute based on the modified biological process associated with the first defect, the simulated biological attribute being substantially consistent with at least one corresponding biological attribute associated with diabetes in a reference pattern of diabetes.

12. The computer executable software code of claim 10, further comprising:

code to receive a user-specified identification of a second defect indicator from the plurality of predefined defect indicators, a second defect from the plurality of defects being associated with the second defect indicator, the parameter set associated with each biological processes that is associated with the second defect being changed based on the user-specified identification.

13. The computer executable software code of claim 12, wherein:

the first defect has an associated severity based on the change to the at least one associated parameter set; and

the second defect has an associated severity based on the change to the at least one associated parameter set, the severity associated with the first defect being different from the severity associated with the second defect.

14. The computer executable software code of claim 12, wherein:

the first defect has an associated severity based on the change to the at least one associated parameter set; and

the second defect has an associated severity based on the change to the at least one associated parameter set, the severity associated with the first defect being substantially similar to the severity associated with the second defect.

15. The computer executable software code of claim 10, further comprising:

code to produce a simulated biological attribute based on the parameter set associated with each biological processes that is associated with the first defect, the simulated biological attribute being substantially consistent with biological attributes of a reference pattern of diabetes.

16. A computer executable software code, comprising:

code to provide a plurality of predefined defect indicators, each predefined defect indicator from the plurality of predefined defect indicators being uniquely associated with a defect from a plurality of defects associated with a disease state, each defect from the plurality of defects being associated with at least one biological process from a set of biological processes, the set of biological processes being related to glucose metabolism in the context of multiple macronutrient metabolism;

code to receive a user-specified identification oaf first defect indicator from the plurality of predefined defect indicators, a first defect from the plurality of defects being associated with the first defect indicator, the first defect being associated with at least one biological process and its associated parameter set, the at least one parameter set associated with the first defect being changed based on the user-specified identification; and

code to receive a user-specified identification of a second defect indicator from the plurality of predefined defect indicators, a second defect from the plurality of defects being associated with the second defect indicator, the second defect being associated with at least one biological process and its associated parameter set, the at least one parameter set associated with the second defect being changed based on the user-specified identification.

17. The computer executable software code of claim 16, wherein:

the first defect having an associated severity based on the change to the at least one associated parameter set, the second defect having an associated severity based on the change to the at least one associated parameter set, the severity associated with the first defect being different from the severity associated with the second defect.

18. The computer executable software code of claim 16, further comprising:

code to define a normal biological state through the set of biological processes, each biological process from the set of biological processes being associated with its own parameter set.

19. The computer executable software code of claim 16, wherein the plurality of defects are associated with type 2 diabetes.

20-28. -28. (canceled)