APPARATUS, COMPUTER-ACCESSIBLE MEDIUM AND METHOD FOR MEASURING CHEMICAL AND/OR MOLECULAR COMPOSITIONS OF CORONARY ATHEROSCLEROTIC PLAQUES IN ANATOMICAL STRUCTURES

• US 20090073439A1
• Filed: 09/15/2008
• Published: 03/19/2009
• Est. Priority Date: 09/15/2007
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Chau, Alexandra H., Motz, Jason T., Tearney, Guillermo J., Gardecki, Joseph A., Bouma, Brett E.
• Application Number:
  US12/210,979
• Publication Number:
  US 20090073439A1
• Time in Patent Office: Days
• US Class Current: 356/337
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance

Abstract

Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.

Claims

1. An apparatus for controlling at least one electro-magnetic radiation, comprising:

a particular arrangement which is configured to at least one of rotate or translate at least one optical waveguide, wherein at least one of the at least one optical waveguide receives a first radiation at a first wavelength and transmits the first radiation to at least one sample, wherein the at least one or another one of the at least one optical waveguide receives a second radiation at a second wavelength that is different from the first wavelength, and wherein the second radiation is produced based on an inelastic scattering of the first radiation.

2. The apparatus according to claim 1, further comprising:

a processing arrangement configured to receive data associated with the second radiation, and determine at least one characteristic of the at least one sample based on the data.

3. The apparatus according to claim 2, wherein the processing arrangement generates at least one image or at least one map of at least one portion of the at least one sample based on the at least one characteristic.

4. The apparatus according to claim 3, wherein the at least one characteristic is a chemical characteristic.

5. The apparatus according to claim 3, wherein the at least one of the image or the map includes a ratio of different chemical characteristics.

6. The apparatus according to claim 1, wherein the at least one waveguide includes at least one fiber.

7. The apparatus according to claim 6, wherein the at least one fiber includes a plurality of fibers or a fiber bundle.

8. The apparatus according to claim 7, wherein one of the fibers receives the first radiation, and at least another one of the fibers receives the second radiation.

9. The apparatus according to claim 7, wherein a particular fiber of the fibers receives the first and second radiations.

10. The apparatus according to claim 1, further comprising a spectral separating arrangement which is configured to transmit the first radiation to the at least one waveguide, and reflect the second radiation.

11. The apparatus according to claim 10, wherein the spectral separating arrangement is at least one of a spatial filter, a dichroic mirror, a grating or a prism.

12. The apparatus according to claim 1, further comprising a spectral separating arrangement which is configure to reflect the first radiation to the at least one waveguide, and transmit the second radiation.

13. The apparatus according to claim 12, wherein the spectral separating arrangement is at least one of a spatial filter, a dichroic mirror, a grating or a prism.

14. An apparatus for generate at least one image or at least one map of at least one portion of at least one arterial sample, comprising:

a first arrangement receives a first radiation at a first wavelength, transmits the first radiation to the at least one arterial sample, and receives a second radiation at a second wavelength that is different from the first wavelength, wherein the second radiation is produced based on an inelastic scattering of the first radiation, and wherein the first radiation illuminates at least one luminal aspect of the at least one portion; and

a second processing arrangement configured to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the at least one image or the at least one map of the at least one portion of the at least one arterial sample based on the at least one characteristic.

15. The apparatus according to claim 14, wherein the at least one characteristic is a chemical characteristic.

16. The apparatus according to claim 14, wherein the at least one of the image or the map includes a ratio of different chemical characteristics.

17. The apparatus according to claim 14, wherein the at least one arterial sample includes a coronary artery.

18. The apparatus according to claim 14, wherein the at least one arterial sample is in-vivo.

19. Computer accessible medium which includes a software arrangement thereon, wherein, when a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using procedures comprising:

simulating at least one electro-magnetic radiation provided into and out of the arrangement;

simulating an inelastic scattering radiation from at least one simulated sample;

receiving the simulated inelastic scattering radiation into and out of the simulated arrangement;

determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.

20. The computer accessible medium according to claim 19, wherein the simulation of the inelastic scattering radiation is performed using at least one of a Monte-Carlo technique or a ray-tracing procedure.

21. The computer accessible medium according to claim 19, wherein the simulation of the at least one electro-magnetic radiation is performed using at least one of a Monte-Carlo technique or a ray-tracing procedure.

22. The computer accessible medium according to claim 19, wherein the simulated arrangement is a catheter.

23. The computer accessible medium according to claim 19, wherein the at least one simulated sample is at least one of an anatomical structure or a fluid.

24. The computer accessible medium according to claim 19, wherein the anatomical structure is an artery.

25. The computer accessible medium according to claim 19, wherein the fluid is blood or a transparent fluid.

26. The computer accessible medium according to claim 19, wherein the processing arrangement is further configured to modify the simulated arrangement so as to change the characteristic.

27. The computer accessible medium according to claim 19, wherein the processing arrangement is further configured to compare the simulated characteristic with an actual characteristic of an actual arrangement, and determine a further characteristic of an actual sample based on the comparison.

28. The computer accessible medium according to claim 26, wherein the comparison is performed using a least squared minimization technique.