LIQUID TRANSFER DEVICE

• US 20090074624A1
• Filed: 05/21/2008
• Published: 03/19/2009
• Est. Priority Date: 09/19/2007
• Status: Abandoned Application

• Current Assignee: Don Liang
• Original Assignee: Don Liang
• Inventors: Liang, Don
• Application Number:
  US12/124,738
• Publication Number:
  US 20090074624A1
• Time in Patent Office: Days
• US Class Current: 422/100
• CPC Class Codes: B01L 2300/041 Connecting closures to device or container
• CPC Class Codes: B01L 2300/044 pierceable, e.g. films, membranes
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 3/021 Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 3/50855 using modular assemblies of strips or of individual wells
• CPC Class Codes: B01L 9/523 for multisample carriers, e.g. used for microtitration plates
• CPC Class Codes: G01N 35/10 Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices G01N35/0099 takes precedence

Abstract

A liquid transfer device is provided for biochemical assay, including a pipette forming an interior space extending in an axial direction and having first and second ends. The first end forms an opening and the second end forms an enclosed variable volume, whereby variation of the volume causes a change of pressure to selectively induce a suction force and a releasing force in the pipette. An analysis container includes a plurality of receptacles retained by a slab. A film covers the slab to seal the container. A movement control device includes a manipulator that releasably holds the pipette and a tray that forms a cavity for receiving and retaining the container. The pipette and the tray are movable with respect to each other in order to fill/draw test agent into/out of the receptacles.

Claims

1. A liquid transfer device comprising:

a pipette forming an interior space extending in an axial direction and having first and second ends, the first end forming an opening and the second end forming an enclosed variable volume, whereby variation of the volume causes change of pressure, which selectively induces a suction force or a releasing force in the pipette, the pipette further comprising at least one fixing section;

an analysis container forming a plurality of receptacles which is retained by a slab, the analysis container comprising a lock section;

cover means comprising a cover film that covers a surface of the slab to seal the analysis container; and

movement control means comprising a manipulator and a tray, the tray forming a cavity receiving the analysis container therein and a retention section engageable with the lock section to secure the analysis container to the tray.

2. The liquid transfer device as claimed in claim 1, wherein the second end of the pipette comprises an enclosed volume-variable bladder that defines the variable volume of the second end of the pipette, the bladder comprising a bellow structure made of an elastic material, and extending in an axial direction of the pipette or in a direction transverse to the axial direction.

3. The liquid transfer device as claimed in claim 1, wherein the second end of the pipette comprises an enclosed volume-variable bladder that defines the variable volume of the second end of the pipette, the bladder comprising an elastic structure having a spherical shape.

4. The liquid transfer device as claimed in claim 1, wherein the manipulator comprises at least one coupling member for engaging and retaining the fixing section of the pipette.

5. The liquid transfer device as claimed in claim 1, wherein the movement control means comprises a driving mechanism for inducing an action force to the pipette to cause the variation of the volume of second end of the pipette to selectively generate the suction force and the releasing force.

6. The liquid transfer device as claimed in claim 1, wherein the fixing section selectively comprises a groove, a circumferential slot, and a hole.

7. The liquid transfer device as claimed in claim 1, wherein the slab forms an opening in which an individual receptacle is received and held, the individual receptacle functioning as a final product collection receptacle and located at an end of the slab, the individual receptacle comprising a cover.

8. The liquid transfer device as claimed in claim 1, wherein the receptacles include a magnetic separation receptacle having a substantially flat bottom having a sloped surface for retaining magnetic beads that are disposed in the magnetic separation receptacle for carrying out magnetic separation operation.

9. The liquid transfer device as claimed in claim 1, wherein the receptacles include temperature-controlled receptacles for realizing temperature control for the liquid transfer device.

10. The liquid transfer device as claimed in claim 7, wherein the slab has a surface on which a tip portion is formed at a location close to the opening for the final product collection receptacle.

11. The liquid transfer device as claimed in claim 1, wherein the pipette and the tray carried by the movement control means are relatively movable with respect to each other so that a relatively movable relationship is formed therebetween, the relatively movable relationship being selected from one of a first relationship wherein the pipette is movable in both horizontal and vertical directions, while the tray is kept stationary, a second relationship wherein the pipette is moved in the horizontal direction, while the tray is movable in the vertical direction, or a third relationship wherein the pipette is movable in a vertical direction, while the tray is movable in the horizontal direction.

12. A pipette adapted to use in a liquid transfer device, comprising a hollow member extending in an axial direction and having first and second ends in the axial direction, the first end forming an opening, the second end forming an enclosed variable volume, whereby the variation of the volume causes change of pressure to selectively induce a suction force or a releasing force in the pipette, the pipette comprising at least one fixing section.

13. The pipette as claimed in claim 12, wherein the fixing section selectively comprises a groove, a circumferential slot, and a hole those adapted to engage an external component.

14. The pipette as claimed in claim 12, wherein the second end of the pipette comprises an enclosed volume-variable bladder that defines the variable volume of the second end of the pipette, the bladder comprising a bellow structure made of an elastic material, and extending in an axial direction of the pipette or in a direction transverse to the axial direction.

15. The pipette as claimed in claim 12, wherein the second end of the pipette comprises an enclosed volume-variable bladder that defines the variable volume of the second end of the pipette, the bladder comprising an elastic structure having a spherical shape.

16. A container for use in a liquid transfer device comprising a plurality of receptacles retained by a slab, the container further comprising a lock section, and cover means comprising a film covering a surface of the slab.

17. The container as claimed in claim 16, wherein the lock section is engageable a retention member formed in an external component to be secured to the external component.

18. The container as claimed in claim 16, wherein the slab forms an opening in which an individual receptacle is received and retained, the individual receptacle functioning as a final product collection receptacle and located at an end of the slab, the individual receptacle comprising a cover, and wherein the slab has a surface on which a tip portion is formed at a location close to the opening for the final product collection receptacle.

19. The container as claimed in claim 16, wherein the receptacles include a magnetic separation receptacle having a substantially flat bottom having a sloped surface for retaining magnetic beads that are disposed in the magnetic separation receptacle for carrying out magnetic separation operation.

20. The container as claimed in claim 16, wherein the receptacles include temperature-controlled receptacles for realizing temperature control for the liquid transfer device.