AUGMENTATION AND REPAIR OF SPINCTER DEFECTS WITH CELLS INCLUDING FIBROBLASTS
First Claim
1. A method for repair or augmentation of a tissue defect in a subject, comprising choosing a sphincter structure malfunction as the defect, and placing within or proximal to the tissue defect site a composition comprising an enriched population of in vitro cultured mammalian fibroblasts to repair or augment the sphincter structure malfunction.
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Abstract
An embodiment of the invention includes methods for the long-term augmentation and/or repair of skin defects (scars, skin laxness, skin thinning, and skin augmentation), cellulite, breast tissue, wounds and burns, urological and gastroesophageal sphincter structures, hernias, periodontal disease and disorders, tendon and ligament tears and baldness, by the injection or direct surgical placement/implantation of autologous cultured cells and/or cultured cell-produced extracellular matrix that is derived from connective tissue, dermis, fascia, lamina propria, stroma, adipose tissue, muscle, tendon, ligament or the hair follicle. The corrective application is done on tissue proximal or within the area of the defect. The method involves retrieving viable cells from the subject, a neonate or human fetus. Alternatively, the corrective application involves the cells placed in a matrix, preferably comprised of autologous extracellular matrix constituents as a three-dimensional structure or as a suspension, prior to placement into a position with respect to the subject'"'"'s defect. In a further embodiment, the preferable autologous extracellular matrix constituents are collected from culture and placed in a position with respect to the subject'"'"'s defect.
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Citations
25 Claims
- 1. A method for repair or augmentation of a tissue defect in a subject, comprising choosing a sphincter structure malfunction as the defect, and placing within or proximal to the tissue defect site a composition comprising an enriched population of in vitro cultured mammalian fibroblasts to repair or augment the sphincter structure malfunction.
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25. A composition for repairing or augmenting a sphincter malfunction defect proximal or within the defect, the composition comprising in vitro cultured mammalian fibroblasts.
Specification