Compounds to treat alzheimer's disease
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Abstract
The present invention is substituted amines of formula (X)
useful in treating Alzheimer'"'"'s disease and other similar diseases.
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Citations
76 Claims
- 1. A substituted amine of formula (X)
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38. A method of treating a patient who has, or in preventing a patient from getting, a disease or condition selected from the group consisting of Alzheimer'"'"'s disease, for helping prevent or delay the onset of Alzheimer'"'"'s disease, for treating patients with mild cognitive impairment (MCI) and preventing or delaying the onset of Alzheimer'"'"'s disease in those who would progress from MCI to AD, for treating Down'"'"'s syndrome, for treating humans who have Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-Type, for treating cerebral amyloid angiopathy and preventing its potential consequences, i.e. single and recurrent lobar hemorrhages, for treating other degenerative dementias, including dementias of mixed vascular and degenerative origin, dementia associated with Parkinson'"'"'s disease, dementia associated with progressive supranuclear palsy, dementia associated with cortical basal degeneration, diffuse Lewy body type of Alzheimer'"'"'s disease and who is in need of such treatment which comprises administration of a therapeutically effective amount of a compound selected from the group consisting of:
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N1-[(1S,2S)-1-(3,5-difluorobenzyl)-3-(hexylamino)-2-hydroxypropyl]-N3,N3-dipropylisophthalamide, N1-[(1S,2S)-3—
(benzylamino)-1-(3,5-difluorobenzyl)-2-hydroxypropyl]-5-methyl-N3,N3-dipropylisophthalamide,N1-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-methyl-N3,N3-dipropylisophthalamide, and N1-(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-3-{[(1S)-2-(isobutylamino)-1-methyl-2-oxoethyl]amino}propyl)-N3,N3-dipropylisophthalamide; and a pharmaceutically acceptable salt thereof.
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Specification