LIPOPLEX FORMULATIONS FOR SPECIFIC DELIVERY TO VASCULAR ENDOTHELIUM
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention is related to a lipid composition contained in and/or containing a carrier comprising at least a first lipid component, at least a first helper lipid, and a shielding compound which is optionally removable from the lipid composition under in vivo conditions, whereby the lipid composition containing carrier has an osmolarity of about 50 to 600 mosmole/kg, preferably about 250-350 mosmole/kg, and more preferably about 280 to 320 mosmole/kg, and/or whereby liposomes formed by the first lipid component and/or one or both of the helper lipid and the shielding compound in the carrier have a particle size of about 20 to 200 nm, preferably about 30 to 100 nm, and more preferably about 40 to 80 mm.
-
Citations
110 Claims
-
1-75. -75. (canceled)
-
76. A lipid composition contained in and/or containing a carrier comprising:
-
at least a first lipid component, at least a first helper lipid, and a shielding compound that may be removable from the lipid composition under in vivo conditions, wherein the lipid composition containing carrier has an osmolarity of about 50 to 600 mosmole/kg, about 250-350 mosmole/kg, or about 280 to 320 mosmole/kg, and/or wherein liposomes formed by the first lipid component and/or one or both of the helper lipid and the shielding compound in the carrier have a particle size of about 20 to 200 nm, about 30 to 100 nm, or about 40 to 80 nm. - View Dependent Claims (77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 105, 106, 107, 108, 109, 110)
-
-
102. A lipoplex comprising:
-
a) a positively charged liposome consisting of; aa) about 50 mol % β
3-arginyl-2,3-diaminopropionic acid-N-palmityl-N-oleyl-amide trihydrochloride, (β
-(L-arginyl)-2,3-L-diaminopropionic acid-N-palmityl-N-oleyl-amide tri-hydrochloride);ab) about 48 to 49 mol % 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine (DPhyPE); and ac) about 1 to 2 mol % 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylen-glycole, N—
(Carbonyl-methoxypolyethyleneglycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt; andb) a functional nucleic acid, a siRNA. - View Dependent Claims (103, 104)
-
Specification