Dip coated compositions containing copolymer of polyvinyl alcohol and polyethylene glycol and a gum

• US 20090074866A1
• Filed: 09/15/2008
• Published: 03/19/2009
• Est. Priority Date: 09/17/2007
• Status: Abandoned Application

• Current Assignee: McNeil-PPC Incorporated (Johnson & Johnson)
• Original Assignee: McNeil-PPC Incorporated (Johnson & Johnson)
• Inventors: Chen, Jen-Chi
• Application Number:
  US12/210,324
• Publication Number:
  US 20090074866A1
• Time in Patent Office: Days
• US Class Current: 424/481
• CPC Class Codes: A61K 9/2072 characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms A61K9/0004, A61K9/0056, A61K9/0065 take precedence
• CPC Class Codes: A61K 9/2886 having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer of the type active core-drug layer-inactive layer A61K9/209
• CPC Class Codes: A61K 9/2893 Tablet coating processes mechanical aspects A61J3/06

Abstract

In one aspect, the present invention features a method of making a coated tablet, by dipping a core including an active agent into a coating liquid and drying the dipped core to form a outer-coating on said core, wherein the coating liquid includes (i) at least one copolymer of polyvinyl alcohol and polyethylene glycol, (ii) at least one gum, and (iii) a solvent for the at least one copolymer of polyvinyl alcohol and polyethylene glycol and the at least one gum and coated tablets manufactured by such method.

Claims

1. A method of making a coated tablet, said method comprising dipping a core comprising an active agent into a coating liquid and drying said dipped core to form a outer-coating on said core, wherein said coating liquid comprises (i) at least one copolymer of polyvinyl alcohol and polyethylene glycol, (ii) at least one gum, and (iii) a solvent for said at least one copolymer of polyvinyl alcohol and polyethylene glycol and said at least one gum.

2. A method of claim 1, wherein said at least one gum is selected from the group consisting of xanthan gum, locust bean gum, tara gum, and mixtures thereof.

3. A method of claim 1, wherein said coating liquid comprises at least two gums.

4. A method of claim 1, wherein said coating liquid comprises both xanthan gum and locust bean gum.

5. A method of claim 1, wherein said coating liquid further comprises at least one thickener that is not a gum.

6. A method of claim 1, wherein the weight ratio of said at least one copolymer of polyvinyl alcohol and polyethylene glycol to said at least one gum is from about 25:

1 to about 75;

1.

8. A method of claim 1, wherein said coating liquid comprises, based upon the total weight of the coating liquid,

a) from about 15 percent to about 35 percent of said at least one copolymer of said polyvinyl alcohol and polyethylene glycol;

and

b) from about 0.05 percent to about 1.0 percent of said at least one gum.

9. A method of claim 1, wherein the resulting outer-coating comprises, based upon the total dried weight of the outer-coating,

a) from about 85 percent to about 99.9 percent of said at least one copolymer of polyvinyl alcohol and polyethylene glycol;

and

b) from about 0.1 percent to about 15 percent of said at least one gum.

11. A method of claim 1, wherein said core has a first end and a second end, and said method comprising dipping said first end of the core into said coating liquid and said method further comprises dipping said second end in a second coating liquid, wherein said second coating liquid is a different color from said coating liquid.

12. A method of claim 1, wherein said coating substantially covers the surface of said core.

13. A method of claim 1, wherein said method further comprises creating one or more openings in said coating to exposes said core on the surface of said coated tablet.

14. A method of claim 1, wherein the viscosity of the coating liquid is from about 500 to about 3000 cps.

15. A method of claim 1, wherein said solvent comprises water.

16. A method of claim 1, wherein said core comprises a subcoating-layer on the surface of said core.

17. A method of claim 1, wherein the percent solids of the coating liquid is from about 20 to about 30.

18. A coated tablet manufactured by the method of claim 1.

19. A coated tablet of claim 18, wherein the resulting outer-coating comprises, based upon the total dried weight of the outer-coating,

a) from about 85 percent to about 99.9 percent of said at least one copolymer of polyvinyl alcohol and polyethylene glycol;

and

b) from about 0.1 percent to about 15 percent of said at least one gum.

20. A coated tablet of claim 18, wherein said coating comprises, based upon the total dried weight of the coating,

a) from about 90 percent to about 99 percent of said at least one copolymer of polyvinyl alcohol and polyethylene glycol;

and

b) from about 0.5 percent to about 2 percent of locust bean gum; and

c) from about 0.5 percent to about 2 percent of xanthan gum.

21. A method of claim 1, wherein said dried coating possesses a surface gloss of at least 250.

7. (canceled)

10. A method of claim 1, wherein said coating comprises, based upon the total dried weight of the coating,

a) from about 90 percent to about 99 percent of said at least one copolymer of polyvinyl alcohol and polyethylene glycol;

and

b) from about 0.5 percent to about 2 percent of locust bean gum; and

c) from about 0.5 percent to about 2 percent of xanthan gum.

10-1. (canceled)