Please download the dossier by clicking on the dossier button x
×

HSP90 INHIBITORS CONTAINING A ZINC BINDING MOIETY

  • US 20090076006A1
  • Filed: 09/10/2008
  • Published: 03/19/2009
  • Est. Priority Date: 09/10/2007
  • Status: Abandoned Application
First Claim
Patent Images

1. A compound represented by formula I or II:

  • or its geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Cy and Cy1 are each independently selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, cycloalkyl and substituted cycloalkyl;

    X and Y are independently O, S, N, NR8 or CR8, where R8 is hydrogen, acyl, aliphatic or substituted aliphatic;

    W is hydrogen, hydroxy, substituted hydroxy, amino, substituted amino, thiol, substituted thiol, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylamino, substituted or unsubstituted dialkylamino, CF3, CN, NO2, N3, acyl, aliphatic or substituted aliphatic, C(O)W10;

    where W10 is OR′

    , SR′ and

    NR7R8, wherein R7 is hydrogen, OR′

    , aliphatic or substituted aliphatic;

    R′

    is hydrogen, aliphatic, substituted aliphatic or acyl; and

    R8 is hydrogen, acyl, aliphatic or substituted aliphatic;

    or R7 and R8 together with nitrogen atom to which they are attached to form a heterocyclic ring;

    B is linker;

    C is selected from;

    (a)

    where W1 is O or S;

    Y1 is absent, N, or CH;

    Z1 is N or CH;

    R7 and R9 are independently hydrogen, OR′

    , aliphatic or substituted aliphatic, wherein R′

    is hydrogen, aliphatic, substituted aliphatic or acyl;

    provided that if R7 and R9 are both present, one of R7 or R9 must be OR′ and

    if Y is absent, R9 must be OR′

    ; and

    R8 is hydrogen, acyl, aliphatic or substituted aliphatic;

    (b)

    where W1 is O or S;

    J is O, NH or NCH3; and

    R10 is hydrogen or lower alkyl;

    (c)

    where W1 is O or S;

    Y2 and Z2 are independently N, C or CH; and

    (d)

    where Z1, Y1, and W1 are as previously defined;

    R11 and R12 are independently selected from hydrogen or aliphatic;

    R1, R2 and R3 are independently selected from hydrogen, hydroxy, amino, halogen, alkoxy, substituted alkoxy, alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfonyl, CF3, CN, NO2, N3, sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×