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DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS

  • US 20090076275A1
  • Filed: 09/10/2008
  • Published: 03/19/2009
  • Est. Priority Date: 09/19/2007
  • Status: Abandoned Application
First Claim
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1. A compound of formula (I):

  • wherein;

    R1 is H, lower alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl;

    R2 is H, lower alkyl, haloloweralkyl or lower alkyl-alkoxy;

    R3 is H, amino or ═

    O;

    R4 is H or ═

    O or absent R5 is lower alkyl, lower alkyl-alkoxy, alkoxyalkoxyalkyl, CH2C(O)OCH3, cycloalkyl,heterocycloalkyl, lower alkyl-hydroxy, aryl, heteroaryl, lower alkyl-aryl or lower alkyl-heteroaryl;

    R6 is H, lower alkyl or alkoxy;

    R7 is H, lower alkyl or alkoxy;

    R8 is H, lower alkyl, haloalkyl or absent;

    X is S, C, O or N;

    Y is C or N;

    Z is C, N, O or S; and

    A, D, E, G, independently of each other, is C or N, and pharmaceutically acceptable salts thereof.

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