Drug Delivery from Electroactive Molecularly Imprinted Polymer

• US 20090076437A1
• Filed: 11/06/2008
• Published: 03/19/2009
• Est. Priority Date: 03/12/2005
• Status: Active Grant

• Current Assignee: Jenny Ulyanova, Shelley D. Minteer
• Original Assignee: Jenny Ulyanova, Shelley D. Minteer
• Inventors: Ulyanova, Jenny, Minteer, Shelley D.
• Granted Patent: US 8,216,300 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: H01M 8/16 Biochemical fuel cells, i.e. cells in which microorganisms function as catalysts
• CPC Class Codes: Y02E 60/50 Fuel cells

Abstract

A device delivers a chemical or biological agent, the device comprises an imprint molecule (IM) to be delivered by the device; an electroactive molecularly imprinted polymer (EMIP) imprinted with the imprint molecule, the EMIP having a plurality of binding sites capable of binding the imprint; and an electric potential producing member (EPM), the EPM being capable of producing an electric potential between the EPM and the EMIP; whereby when the EMIP has a predetermined density of imprint molecule bound at the binding sites, and whereby when a sufficient potential is produced between the EPM and the EMIP, the imprint molecule is released from the binding site and thereby delivered by the device.

Claims

1. A device for delivery of a chemical or biological agent comprising:

a first imprint molecule (IM) comprising said chemical or biological agent to be delivered by said device;

a first electroactive molecularly imprinted polymer (EMIP) imprinted with said first imprint molecule, said EMIP also having a plurality of binding sites capable of binding said first imprint molecule, said binding sites characterized by a binding affinity between said binding site and said first imprint molecule; and

an electric potential producing member (EPM), said EPM capable of creating an electric potential between said EPM and said EMIP;

wherein said EMIP has a predetermined density of said first imprint molecule bound at said binding sites; and

wherein when a sufficient potential is produced between said EPM and said EMIP, said binding affinity between said binding site and said first imprint molecule is decreased so that said first imprint molecule is released from said binding site and thereby delivered by said device.

2. The device of claim 1, wherein said binding sites are capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said first imprint molecule and said binding site existing in said first electroconformation is greater than said binding affinity between said first imprint molecule and said binding site existing in said second electroconformation, and wherein said sufficient potential produced between said EPM and said EMIP results in said transition of said binding site between said first electroconformation and said second electroconformation.

3. The device of claim 1, wherein said first imprint molecule is capable of transitioning between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said binding site and said first imprint molecule existing in said first electroconformation is greater than said binding affinity between said binding site and said first imprint molecule existing in said second electroconformation, and wherein said sufficient potential produced between said EPM and said EMIP results in said transition of said first imprint molecule between said first electroconformation and said second electroconformation.

4. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is capable of participating in electron transfer.

5. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is capable of undergoing a redox reaction at said binding site.

6. The device of claim 1, wherein said first electroactive molecularly imprinted polymer is a conducting polymer.

7. The device of claim 1, wherein said electroactive molecularly imprinted polymer is of the class termed polyazine.

8. The device of claim 1, wherein said electroactive molecularly imprinted polymer is one of poly (methylene green), poly (methylene blue), poly (neutral red) or poly (phenol red).

9. The device of claim 1, wherein said EPM is selected from the group consisting of a potentiometer, a biofuel cell, and an EMIP.

10. The device of claim 1 wherein said delivery of said chemical or biological agent is dependent upon the detection of an analyte as a result of said potential produced by said EPM being dependent upon the detection of said analyte.

11. The device of claim 10, wherein said EPM is a second electroactive molecularly imprinted polymer imprinted with a second imprint molecule and having a plurality of binding sites, each binding site being capable of binding said second imprint molecule in a manner characterized by a certain binding affinity between said binding site and said second imprint molecule, and wherein the binding of said second imprint molecule in said binding site allows for the generation of said potential.

12. The device of claim 11, wherein said second imprint molecule can transition between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said binding site of said second electroactive molecularly imprinted polymer and said second imprint molecule existing in said first electroconformation is greater than said binding affinity between said binding site of said second electroactive molecularly imprinted polymer and said second imprint molecule existing in said second electroconformation.

13. The device of claim 11, wherein said binding site of said second electroactive molecularly imprinted polymer can transition between at least a first electroconformation and a second electroconformation, and wherein said binding affinity between said second imprint molecule and said binding site of said second electroactive molecularly imprinted polymer existing in said first electroconformation is greater than said binding affinity between said second imprint molecule and said binding site of said second electroactive molecularly imprinted polymer existing in said second electroconformation.

14. The device of claim 10, wherein said means for creating electric potential is a biofuel cell.