SYSTEMS AND METHODS EMPLOYING FORCE SENSING FOR MAPPING INTRA-BODY TISSUE

• US 20090076476A1
• Filed: 08/15/2008
• Published: 03/19/2009
• Est. Priority Date: 08/15/2007
• Status: Abandoned Application

• Current Assignee: Hansen Medical Incorporated (Johnson & Johnson)
• Original Assignee: Hansen Medical Incorporated (Johnson & Johnson)
• Inventors: Barbagli, Federico, Carlson, Christopher R., Tanner, Neal A., Sewell, Christopher M.
• Application Number:
  US12/192,974
• Publication Number:
  US 20090076476A1
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61B 2090/064 for measuring force, pressure or mechanical tension
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/6885 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 90/06 Measuring instruments not otherwise provided for

Abstract

A medical instrument system includes a controller and a guide instrument coupled to an instrument driver, the instrument driver configured to manipulate a distal end portion of the guide instrument in response to control signals generated by the controller. A force sensor is associated with the guide instrument or with a working instrument carried by the guide instrument, and generates force signals responsive to a force applied to a respective distal end portion of the guide instrument or working instrument. A position determining system generates position data indicative of a position of the respective guide or working instrument distal end portion associated with the force sensor, and a processor operatively coupled to the force sensor and position determining system processes respective force signals and position data to generate and display a geometric rendering of an internal body tissue surface based on sensed forces applied to the respective instrument distal end portion as the guide instrument is maneuvered within an interior region of a body containing the body surface.

Claims

1. A medical instrument system, comprising:

a controller;

an instrument driver in communication with the controller;

an elongate instrument coupled to the instrument driver, the instrument driver configured to manipulate a distal end portion of the instrument in response to control signals generated by the controller;

a force sensor associated with the instrument, wherein the force sensor generates force signals responsive to a force applied to the distal end portion of the instrument;

a position determining system which generates position data indicative of a position of the distal end portion of the instrument;

a processor operatively coupled to the force sensor and position determining system, and configured to process the respective force signals and position data to generate a geometric rendering of an internal body tissue surface based at least in part upon sensed forces applied to the distal end of the instrument as it is maneuvered within an interior region of a body containing the body surface; and

a display coupled to the processor for displaying the geometric rendering of an internal body tissue surface.

2. The system of claim 1, wherein the processor is configured to determine a characteristic of tissue at a location on the tissue surface based on a sensed force applied to the distal end portion of the instrument as the instrument is maneuvered against the tissue surface at the respective location.

3. The system of claim 2, wherein the determined tissue characteristic is a measure of tissue stiffness or compliance.

4. The system of claim 3, wherein the processor causes regions of the body tissue area in the map having differences in tissue compliance to be visually highlighted on the display.

5. The system of claim 1, wherein the force sensor is coupled to the distal end portion of the instrument.

6. They system of claim 5, wherein the force sensor comprises a unidirectional force sensor that senses force applied substantially normal to a longitudinal axis of the instrument.

8. The system of claim 1, wherein the processor is configured to generate the graphic rendering of the tissue surface by identifying a plurality of determined positions of the instrument distal end portion within the interior body region at which a substantially same amount of applied force is detected.

9. The system of claim 1, wherein the graphic rendering of the tissue surface includes a first tissue surface boundary determined based upon a first plurality of locations within the interior body region at which a first substantially same amount of force is detected on the distal end portion of the instrument, and a second tissue surface boundary determined based upon a second plurality of locations within the interior body region at which a second substantially same amount of force greater than the first amount is detected on the distal end portion of the instrument.

7. (canceled)

10. (canceled)

11. A medical instrument system, comprising:

a controller;

an instrument driver in communication with the controller;

a guide instrument coupled to the instrument driver, the instrument driver configured to manipulate a distal end portion of the guide instrument in response to control signals generated by the controller;

a working instrument carried by the guide instrument and having a distal tip portion;

a force sensor associated with the working instrument, wherein the force sensor generates force signals responsive to a force applied to a distal end portion of the working instrument;

a position determining system which generates position data indicative of a position of the distal end portion of the working instrument;

a processor operatively coupled to the force sensor and position determining system, and configured to process the respective force signals and position data to generate a geometric rendering of an internal body tissue surface based at least in part upon sensed forces applied to the distal end of the working instrument while it is extended out of a distal opening of the guide instrument and maneuvered by the guide instrument within an interior region of a body containing the body surface; and

a display coupled to the processor for displaying the geometric rendering of an internal body tissue surface.

13. The system of claim 11, wherein the working instrument comprises an ablation or mapping catheter.

12. (canceled)

14-24. -24. (canceled)

25. A method of mapping an area of body tissue, comprising:

(a) maneuvering a distal end portion of an elongate instrument within an interior body region;

(b) determining a position of the instrument distal end portion within the body region;

(c) sensing a force applied to the instrument distal end portion at the determined position;

(d) repeating acts (a) to (c) for a multiplicity of determined positions of, and sensed forces applied to, the instrument distal end portion within the interior body region;

(e) processing the respective determined positions and sensed forces for the multiplicity of determined positions to generate a geometric rendering of an internal body tissue surface located within the interior body region; and

(f) displaying the generated geometric rendering of the body tissue surface.

26. The method of claim 25, wherein processing the respective determined positions and sensed forces to generate a geometric rendering of the internal body tissue surface comprises identifying a plurality of determined positions of the instrument distal end portion within the interior body region at which a substantially same amount of applied force is detected.

27. The method of claim 25, wherein the geometric rendering of the internal body tissue surface includes a first tissue surface boundary determined based upon a first plurality of locations within the interior body region at which a first substantially same amount of force is detected on the instrument distal end portion, and a second tissue surface boundary generated based upon a second plurality of locations within the interior body region at which a second substantially same amount of force greater than the first amount is detected on the instrument distal end portion.

28. The method of claim 27, further comprising determining a characteristic of an area of tissue in the tissue surface based on a relative spacing between the first and second surface boundaries.

29. A method of mapping an area of body tissue, comprising:

(a) maneuvering a distal end portion of an elongate instrument within an interior body region;

(b) sensing forces applied to a distal end portion of the instrument;

(c) determining a position of the instrument distal end portion when a sensed force applied thereto is indicative of tissue surface contact; and

(d) repeating acts (a) to (c) for a multiplicity of determined tissue surface contact positions within the interior body region;

(e) processing the multiplicity of determined positions to generate a geometric rendering of an internal body tissue surface located within the interior body region; and

(f) displaying the generated geometric rendering of the body tissue surface.

30. The method of claim 29, further comprising displaying a representation of the interior body region to an operator to facilitate initial positioning of the instrument distal end within the region under the control of the operator prior to obtaining of the multiplicity of determined positions.

31. The method of claim 29, wherein the instrument is coupled to an instrument driver configured to manipulate the instrument distal end portion in response to control signals generated by a controller.

32. The method of claim 31, wherein the controller causes the instrument distal end to be maneuvered along a determined set of trajectories based on the interior body region.

33. The method of claim 32, wherein the interior body region is selected from a group comprising

a heart chamber,

an anatomical workspace at least partially surrounding an organ exterior surface,

an interior of an organ,

an interior of the gastro-intestinal tract.

37. The method of claim 29, further comprising identifying a tissue anomaly in the tissue surface based on a sensed force or forces applied to the instrument distal end portion as it is maneuvered against the tissue surface.

38. The method of claim 37, further comprising determining and displaying approximate boundaries of the tissue anomaly on the tissue surface.

39. The method claim 37, further comprising treating the tissue anomaly.

40. The method of claim 39, wherein treating the tissue anomaly comprises one or more of

determining approximate boundaries of the tissue anomaly on the tissue surface;

displaying approximate boundaries of the tissue anomaly on a graphic rendering of the tissue surface;

delivering treatment energy to the anomaly;

delivering a treatment substance to the anomaly; and

displaying an area of the anomaly that has been treated on a graphic rendering of the tissue surface.

41. The method of claim 40, wherein one or both of delivering treatment energy to the anomaly and delivering a treatment substance to the anomaly are performed using the instrument.

34-36. -36. (canceled)

42. A medical instrument system, comprising:

a controller having a user interface for receiving operator input commands;

an instrument driver in communication with the controller;

an elongate instrument coupled to the instrument driver, the instrument driver configured to manipulate a distal end portion of the instrument in response to control signals generated by the controller at least partially in response to received operator commands;

a force sensor associated with the instrument, wherein the force sensor generates force signals responsive to a force applied to the distal end portion of the instrument;

a processor operatively coupled to the force sensor and controller, and configured to process the respective force signals to generate applied force data based at least in part upon sensed forces applied to the distal end of the instrument; and

a display coupled to the processor for displaying the applied force data.

43. The system of claim 42, wherein the operator commands include an applied force limit.

44. A method of diagnosing and/or treating internal body tissue, comprising maneuvering a distal end portion of an elongate instrument against an internal body tissue surface until either (i) sensing that a threshold level of force is being applied by the instrument distal end against the tissue surface, or (ii) the instrument distal end is extended to or beyond a determined movement limitation.

45-50. -50. (canceled)

51. A medical instrument system, comprising:

an elongate instrument;

a controller configured to selectively actuate one or more motors operatively coupled to the instrument to thereby selectively move the instrument;

a force sensor associated with the instrument, wherein the force sensor generates force signals responsive to a force applied to the distal end portion of the instrument;

a processor operatively coupled to the force sensor and controller, and configured to process the respective force signals to generate applied force data based at least in part upon sensed forces applied to the distal end of the instrument; and

a haptic input device in communication with the controller and configured for generating instrument motion commands in response to a directional movement of the input device,

wherein the controller transmits signals to the input device to cause the input device to impart a detectable resistance to movement of the input device corresponding to an actual amount of force being applied against the instrument distal end portion.

52. A method of diagnosing and/or treating internal body tissue, comprising:

maneuvering a distal end portion of an elongate instrument against an internal body tissue surface;

sensing an axial force vector applied by the body surface to the instrument distal end portion;

determining an angle of incidence at which the instrument distal end portion is contacting the body surface; and

projecting, based on the sensed axial force vector and determined contact angle of incidence, a component of the axial force in a direction normal to the tissue surface at the contact location.

53. The method of claim 52, further comprising projecting a component of the axial force vector in a direction tangential to the tissue surface at the contact location.