MULTI-TINE PROBE AND TREATMENT BY ACTIVATION OF OPPOSING TINES
First Claim
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1. A method of delivering an electrical field to a tissue, comprising:
- advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, and deploying the plurality of electrodes from a distal portion of a probe so as to at least partially define an ablation volume with the deployed electrodes;
applying an electrical current to the ablation volume so as to provide one or more electric fields extending through the volume and selectively destroying cancerous cells within the volume.
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Abstract
The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or mild hyperthermia, and preferential or selective ablation of cancerous cells of target tissue regions. A method can include, for example, advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, and deploying the plurality of electrodes from a distal portion of a probe, and applying an alternating current so as to provide one or more electric fields extending through the volume and selectively or preferentially destroy cancerous cells within the volume.
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Citations
33 Claims
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1. A method of delivering an electrical field to a tissue, comprising:
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advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, and deploying the plurality of electrodes from a distal portion of a probe so as to at least partially define an ablation volume with the deployed electrodes; applying an electrical current to the ablation volume so as to provide one or more electric fields extending through the volume and selectively destroying cancerous cells within the volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 16)
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13. A method of delivering an electrical field to a tissue, comprising:
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advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells and positioning electrodes of the probe so as to at least partially define an ablation volume with the positioned electrodes; and preferentially ablating cancerous cells of the volume, the ablating comprising delivering a plurality of electric fields extending through an approximate center location of the volume, the plurality of fields comprising a first electric field, a second electric field having an angle relative to the first field, and a third electric field having an angle relative to the first and second fields. - View Dependent Claims (14, 15)
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17. A device for delivering an electric field to a tissue to destroy cancerous cells therein, the device comprising:
a probe having a plurality of electrodes positionable at a target tissue region, the plurality of electrodes deployable from a distal portion of the probe so as to at least partially define an ablation volume, the plurality comprising electrode pairs configured to provide electric fields extending through the volume and preferentially destroying cancerous cells within the volume. - View Dependent Claims (18, 19, 20, 21, 22)
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23. A system for energy delivery and induction of mild hyperthermia in a target tissue region for preferential cancerous tissue ablation, comprising:
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a probe having a plurality of electrodes positionable at a target tissue region, the plurality of electrodes deployable from a distal portion of the probe so as to at least partially define an ablation volume and provide electric fields extending through the volume; an energy source coupled to the device to provide electrical current to induce mild hyperthermia comprising an average tissue temperature less than about 48 degrees C., so as to preferentially ablate cancerous cells of the target tissue disposed in the volume. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
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- 32. The system of claim 32, the selected duration selected from a range of about 15 minutes to about 8 hours.
Specification