Closed Loop Cardiac Resynchronization Therapy Using Cardiac Activation Sequence Information
First Claim
1. A cardiac method, comprising:
- sensing a plurality of composite signals using a plurality of implantable electrodes, the composite signals comprising signal content originating from a plurality of disparate sources and combining to define the composite signals;
performing a source separation using the sensed plurality of composite signals, the source separation separating components of the composite signals according to their respective origins;
producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation;
determining an orientation of the one or more cardiac signal vectors;
comparing the orientation to a baseline value, the comparison of the orientation to the baseline value providing an indication of heart failure status of a patient; and
adjusting a cardiac resynchronization therapy based on the heart failure status of the patient.
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Abstract
Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
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Citations
28 Claims
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1. A cardiac method, comprising:
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sensing a plurality of composite signals using a plurality of implantable electrodes, the composite signals comprising signal content originating from a plurality of disparate sources and combining to define the composite signals; performing a source separation using the sensed plurality of composite signals, the source separation separating components of the composite signals according to their respective origins; producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation; determining an orientation of the one or more cardiac signal vectors; comparing the orientation to a baseline value, the comparison of the orientation to the baseline value providing an indication of heart failure status of a patient; and adjusting a cardiac resynchronization therapy based on the heart failure status of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system, comprising:
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a plurality of implantable electrodes configured for sensing a composite signal, thereby providing a plurality of composite signals comprising signal content originating from a plurality of disparate sources and combining to define the composite signals; a housing configured for implantation in a patient; a controller provided in the housing and coupled to the plurality of implantable electrodes; and a memory provided in the housing and coupled to the controller; wherein the controller is configured to perform a source separation using the sensed composite signals such that the source separation separates components of the composite signals according to their respective origins, and produce one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation, the controller configured to determine an orientation of the one or more cardiac signal vectors, compare the orientation to a baseline value and produce an output indicative of heart failure status of a patient based on the comparison, and adjust a cardiac resynchronization therapy based on the output. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification