METHOD AND PHARMACEUTICAL COMPOSITION FOR INHIBITING PREMATURE RAPTURE OF FETAL MEMBRANES, RIPENING OF UTERINE CERVIX AND PRETERM LABOR IN MAMMALS
First Claim
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1. A method of treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and preterm labor in a pregnant female comprising administering to the pregnant female:
- N-acetyl-cysteine; and
a compound for reversing a low ratio of progesterone effect versus estrogen effect;
thereby treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and/or preterm labor in the pregnant female mammal.
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Abstract
A method and a pharmaceutical composition for inhibiting premature rapture of the fetal membranes, ripening of the uterine cervix and preterm labor of female mammals including human. The method includes the step of administering compounds for reversing at least two biochemical conditions being associated with the above processes. The pharmaceutical composition includes compounds for reversing at least two biochemical conditions being associated with the above processes.
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Citations
19 Claims
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1. A method of treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and preterm labor in a pregnant female comprising administering to the pregnant female:
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N-acetyl-cysteine; and a compound for reversing a low ratio of progesterone effect versus estrogen effect; thereby treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and/or preterm labor in the pregnant female mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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- 8. A pharmaceutical composition for treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and/or preterm labor in a pregnant female pharmaceutical composition comprising, as active ingredients, N-acetyl-cysteine and a compound for reversing a low ratio of progesterone effect versus estrogen effect, the pharmaceutical composition further comprising a pharmaceutically acceptable carrier.
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16. A method of treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and preterm labor in a pregnant female comprising administering to the pregnant female:
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an inhibitor of cervical collagenase; and a compound for reversing a low ratio of progesterone effect versus estrogen effect; thereby treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and/or preterm labor in the pregnant female mammal. - View Dependent Claims (17, 19)
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18. A pharmaceutical composition for treating or preventing premature ripening of the cervix, premature rupture of fetal membranes and/or preterm labor in a pregnant female pharmaceutical composition comprising, as active ingredients, an inhibitor of cervical collagenase and a compound for reversing a low ratio of progesterone effect versus estrogen effect, the pharmaceutical composition further comprising a pharmaceutically acceptable carrier.
Specification