Bi-Functional Polymer-Attached Inhibitors of Influenza Virus
First Claim
1. A virucidal composition comprising two or more antiviral agents coupled to one or more water-soluble, biocompatible polymers.
1 Assignment
0 Petitions
Accused Products
Abstract
Antimicrobial compositions containing two or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. In one embodiment, two or more antiviral agents are covalently coupled to the polymer. Suitable antiviral agents include, but are not limited to, sialic acid, zanamivir, oseltamivir, amantadine, rimantadine, and combinations thereof. The polymer is preferably a water-soluble, biocompatible polymer. Suitable polymers include, but are not limited to, poly(isobutylene-alt-maleic anhydride) (PIBMA), poly(aspartic acid), poly(l-glutamic acid), polylysine, poly(acrylic acid), plyaginic acid, chitosan, carboxymethyl cellulose, carboxymethyl dextran, polyethyleneimine, and blends and copolymers thereof. In another embodiment, the compositions contain a physical mixture of polymer containing one antiviral agent and polymer containing a second antiviral agent. The compositions can be formulated for enteral or parenteral administration. Suitable oral/intranasal dosage forms include, but are not limited to, tablets, capsules, solutions, suspensions, emulsions, syrups, and lozenges. Suitable dosage forms for parenteral administration include, but are not limited to, solutions, suspensions, and emulsions. The compositions described herein are effective at treating a variety of infections, including viral infections such as influenza, while inhibiting or preventing the development of microbial resistance.
-
Citations
27 Claims
- 1. A virucidal composition comprising two or more antiviral agents coupled to one or more water-soluble, biocompatible polymers.
-
17. A method of making a virucidal composition comprising two or more antiviral agents coupled to one or more water-soluble, biocompatible polymers, the method comprising coupling two or more antiviral agents or derivatives thereof to a water-soluble biocompatible polymer.
-
18. The method of making a virucidal composition comprising a physical mixture of a first water-soluble, biocompatible polymer coupled to a first antiviral agent and a second water-soluble, biocompatible polymer coupled to a second antiviral agent, the method comprising coupling a first antiviral agent to a first water-soluble, biocompatible polymer, coupling a second antiviral agent to a second water-soluble, biocompatible polymer, and mixing or blending the polymers together.
- 19. A method of treating or preventing a viral infection, the method comprising administering to a patient in need thereof an effective amount a virucidal composition comprising two or more antiviral agents coupled to one or more water-soluble, biocompatible polymers, the method comprising coupling two or more antiviral agents or derivatives thereof to a water-soluble biocompatible polymer.
- 23. A pharmaceutical composition comprising a virucidal composition comprising two or more antiviral agents coupled to one or more water-soluble, biocompatible polymers, the method comprising coupling two or more antiviral agents or derivatives thereof to a water-soluble biocompatible polymer.
Specification