HIGHLY POROUS, RECOGNITIVE POLYMER SYSTEMS

• US 20090081265A1
• Filed: 12/04/2008
• Published: 03/26/2009
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Peppas, Nicholas A.
• Granted Patent: US 8,741,316 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: C08J 2201/044 Elimination of an inorganic solid phase
• CPC Class Codes: C08J 2201/0444 Salts
• CPC Class Codes: C08J 2201/0446 Elimination of NaCl only
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out

Abstract

The present invention includes compositions, methods, systems of making a composition that includes one or more active agent; a recognitive polymeric matrix; and a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates under conditions of low water or humidity.

Claims

1. A method of making a composition comprising:

polymerizing a recognitive polymeric matrix in the presence of one or more pre-selected imprinting molecules, wherein subsequent exposure of the matrix to the imprinted molecule causes the breakdown of the matrix;

incorporating one or more porosigens into the recognitive polymeric matrix at the time of polymerization;

removing the imprinting molecule(s);

incorporating an active agent upon initial polymerization or after removal of imprinting molecule(s); and

drying the composition.

2. The method of claim 1, wherein the porosigens are selected from carbonates, bicarbonates, sulfates, nitrates, phosphates of alkali metals, ammonium, and combinations thereof.

3. The method of claim 1, wherein the porosigens are selected from sodium chloride, calcium chloride, ammonium carbamate and combinations thereof and have a final weight percent of between 20 and 90 percent of the composition.

4. The method of claim 1, wherein the porosigens are selected from sodium chloride, calcium chloride, ammonium carbamate and combinations thereof and have a mole percent of between 30 and 90 mole percent of the composition during the polymerization of the polymer.

5. The method of claim 1, wherein the rupture of the recognitive polymeric matrix is due to:

osmosis upon the presence and binding of the molecule leading to rupture due to swelling;

change of the solubility of the polymeric network leading to polymer dissolution;

local temperature changes leading to expansion of the polymeric network and combinations thereof.

6. The method of claim 1, wherein the active agent is selected from pharmaceuticals, medical agents, food components, detergents, bleaches, fabric softeners, fragrances, cosmetic products, air fresheners, and active agents used in room deodorant devices, perfumed substrates, perfumed plastics and pet collars.

7. The method of claim 1, wherein the recognitive polymeric matrix is adapted for food and cosmetic applications that use hydrocolloids as the imprinting molecules, wherein the hydrocolloids are extracted from plants, seaweeds or animal collagen, produced by microbial synthesis, comprise polysaccharides, proteins, and combinations thereof.

8. The method of claim 1, wherein the active agent is released upon a change in solubility, pressure, a pH shift, a change in temperature, a temperature increase, enzymatic breakdown, diffusion and combinations thereof.

9. The method of claim 1, wherein the recognitive polymeric matrix is formed into one or more layers.

10. The method of claim 1, wherein the recognitive polymeric matrix is formed into one or more layers, each of which recognizes one or more different molecules and each of which provides a barrier to the release of one or more different active or inert agents or both.

11. The method of claim 1, wherein the recognitive polymeric matrix is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.

12. A composition comprising:

one or more active agents;

a recognitive polymeric matrix that forms a hydrogel in the presence of a recognitive molecule and one or more active agents; and

a porosigen, wherein the composition comprises a porous recognitive, swellable hydrogel that dissociates in the presence of the recognized agent.

13. The composition of claim 12, wherein the swellable hydrogel dissociates under conditions of low water or humidity.

14. The composition of claim 12, wherein the porosigens are selected from carbonates, bicarbonates, sulfates, nitrates, phosphates of alkali metals, ammonium, and combinations thereof.

15. The composition of claim 12, wherein the porosigens are selected from sodium chloride, calcium chloride, ammonium carbamate and combinations thereof and have a final weight percent of between 20 and 90 percent of the composition.

16. The composition of claim 12, wherein the porosigens are selected from sodium chloride, calcium chloride, ammonium carbamate and combinations thereof and have a mole percent of between 30 and 90 mole percent of the composition during the polymerization of the polymer.

17. The composition of claim 12, wherein a loss of structural integrity of the recognitive polymeric matrix is due to:

osmosis upon the presence and binding of the molecule leading to rupture due to swelling;

change of the solubility of the polymeric network leading to polymer dissolution;

local temperature changes leading to expansion of the polymeric network and combinations thereof.

18. The composition of claim 12, wherein the active agent is selected from pharmaceuticals, medical agents, food components, detergents, bleaches, fabric softeners, fragrances, cosmetic products, air fresheners, and active agents used in room deodorant devices, perfumed substrates, perfumed plastics and pet collars.

19. The composition of claim 12, wherein the recognitive polymeric matrix is adapted for food and cosmetic applications, wherein the recognitive molecules comprises a hydrocolloid, wherein the hydrocolloids are extracted from plants, seaweeds or animal collagen, produced by microbial synthesis, and comprise polysaccharides, proteins and combinations thereof.

20. The composition of claim 12, wherein the active agent is released upon a change in solubility, pressure, a pH shift, a change in temperature, a temperature increase, enzymatic breakdown, diffusion and combinations thereof.

21. The composition of claim 12, wherein the recognitive polymeric matrix is formed into one or more layers.

22. The composition of claim 12, wherein the recognitive polymeric matrix is formed into one or more layers, each of which recognizes one or more different molecules and each of which provides a barrier to the release of one or more different active or inert agents or both.

23. The composition of claim 12, wherein the recognitive polymeric matrix is formed into a sphere, film, planar, semi-spherical, cylinder, rod, hemispheres, conical, hemi-cylinders and combination thereof.