CO-ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS
First Claim
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1. A composition comprising:
- pimavanserin, or a salt, a solvate, a polymorph, or an isolated, substantially pure metabolite thereof; and
an agent that ameliorates one or more cholinergic abnormalities.
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Abstract
As disclosed herein, co-administration of pimavanserin with an agent that ameliorates one or more cholinergic abnormalities can have a synergistic effect on the efficacy of the agent. Disclosed herein are compositions which include pimavanserin in combination with an agent that ameliorates one or more cholinergic abnormalities. Also disclosed herein are methods for ameliorating or treating a disease condition characterized by one or more cholinergic abnormalities that can include administering pimavanserin in combination with an agent that ameliorates one or more cholinergic abnormalities.
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Citations
32 Claims
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1. A composition comprising:
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pimavanserin, or a salt, a solvate, a polymorph, or an isolated, substantially pure metabolite thereof; and an agent that ameliorates one or more cholinergic abnormalities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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- 23. A method for ameliorating or treating a disease condition characterized by one or more cholinergic abnormalities, comprising administering a therapeutically effective amount of pimavanserin, or a salt, a solvate, a polymorph, a metabolite or an isolated, substantially pure metabolite thereof in combination with a therapeutically effective amount of an agent that ameliorates one or more cholinergic abnormalities to a subject suffering from the disease condition characterized by one or more cholinergic abnormalities.
Specification