Biosensor comprising interdigitated electrode sensor units
First Claim
1. A biosensor comprising a plurality of independently-operating interdigitated electrode sensor units integrated on a substrate, in which the interdigitated electrode sensor units comprise:
- first electrode and second electrode formed interdigitatedly and spaced from each other on the substrate; and
a sensor-immobilized biomolecule receptor immobilized on the substrate exposed between the first electrode and the second electrode so that the first electrode is electrically connected to the second electrode upon binding to a biomolecule and specifically binding to the biomolecule,wherein the biomolecule is analyzed by the number of the interdigitated electrode sensor units electrically connected by the biomolecule captured by the sensor-immobilized biomolecule receptor.
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Abstract
The present invention is related to a biosensor for detecting presence and concentration of various bio-materials such as genes and proteins by the electrical method, an interdigitated electrode sensor unit for forming the biosensor and a method for measuring concentration of a bio-material using the biosensor. The biosensor according to the present invention comprises a plurality of (a) independently-operating interdigitated electrode sensor units integrated on a substrate, wherein each interdigitated electrode sensor unit comprise: first electrode and second electrode formed interdigitatedly and spaced from each other on the substrate; and a sensor-immobilized biomolecule receptor immobilized on the substrate exposed between the first electrode and the second electrode so that the first electrode is electrically connected to the second electrode upon binding to a biomolecule and specifically binding to the biomolecule, wherein the biomolecule is analyzed by the number of the (b) interdigitated electrode sensor units electrically connected by the biomolecule captured by the sensor-immobilized biomolecule receptor.
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Citations
39 Claims
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1. A biosensor comprising a plurality of independently-operating interdigitated electrode sensor units integrated on a substrate, in which the interdigitated electrode sensor units comprise:
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first electrode and second electrode formed interdigitatedly and spaced from each other on the substrate; and a sensor-immobilized biomolecule receptor immobilized on the substrate exposed between the first electrode and the second electrode so that the first electrode is electrically connected to the second electrode upon binding to a biomolecule and specifically binding to the biomolecule, wherein the biomolecule is analyzed by the number of the interdigitated electrode sensor units electrically connected by the biomolecule captured by the sensor-immobilized biomolecule receptor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A biosensor comprising:
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first electrode and second electrode formed to be spaced from and opposed to each other on the substrate; and a sensor-immobilized biomolecule receptor which is immobilized on the substrate exposed between the first electrode and the second electrode so that the first electrode is electrically connected to the second electrode upon binding to a biomolecule to be analyzed and can specifically bind to the biomolecule; wherein the first electrode and the second electrode are formed by growing a metal reduced by reduction of metallic ion in a solution on a surface having a predetermined metal pattern formed thereon. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification