Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs
First Claim
1. A method of reducing an immune response or an inflammatory reaction, comprising the step of:
- providing to a recipient an implantable material comprisinga biocompatible matrix; and
,anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof,wherein said implantable material is provided to said recipient in an amount sufficient to reduce the immune response or inflammatory reaction in said recipient.
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Accused Products
Abstract
Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity.
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Citations
42 Claims
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1. A method of reducing an immune response or an inflammatory reaction, comprising the step of:
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providing to a recipient an implantable material comprising a biocompatible matrix; and
,anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof, wherein said implantable material is provided to said recipient in an amount sufficient to reduce the immune response or inflammatory reaction in said recipient. - View Dependent Claims (2, 3, 6, 7, 9, 10, 11, 12, 13, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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4. A method of inducing acceptance in a patient, comprising the step of:
providing an implantable material comprising a biocompatible matrix and anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof, prior to, coincident with, or subsequent to transplantation of autograft, xenograft or allograft cells, tissue or organ in said patient in an amount effective to induce acceptance in said patient.
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5. A method of reducing donor antigen immunogenicity, comprising the step of:
providing an implantable material comprising a biocompatible matrix and anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof prior to, coincident with, or subsequent to introduction of said donor antigen to a recipient in an amount effective to reduce donor antigen immunogenicity. - View Dependent Claims (8, 16)
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14. A method of transplanting to a recipient a syngeneic or non-syngeneic cell, tissue or organ transplant, comprising the step of:
providing to said recipient an implantable material comprising a biocompatible matrix and anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof, prior to, coincident with, or subsequent to transplantation such that said transplanted syngeneic or non-syngeneic cell, tissue or organ is not rejected by said recipient. - View Dependent Claims (15, 17)
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36. An implantable material for reducing an immune response to a non-syngeneic cell, tissue or organ, wherein said implantable material comprises:
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a biocompatible matrix; and
, anchored thereto or embedded therein,endothelial cells, endothelial-like cells, or analogs thereof;
ortissue, or organ, or a segment thereof; wherein an effective amount of said implantable material reduces the recipient'"'"'s immune response to said non-syngeneic cell, tissue or organ. - View Dependent Claims (37)
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38. A method of reducing an immune response or an inflammatory reaction resulting from exposure to an exogenous immunogen, comprising the step of:
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providing to a recipient an implantable material comprising a biocompatible matrix; and
,anchored or embedded endothelial cells, endothelial-like cells, or analogs thereof, wherein said implantable material is provided to said recipient in an amount sufficient to reduce the immune response or inflammatory reaction in said recipient resulting from exposure to said exogenous immunogen. - View Dependent Claims (39, 40, 41, 42)
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Specification