MULTI-CHANNEL MICROARRAY APPARATUS AND METHODS
First Claim
1. A multi-channel microarray reader, comprising:
- a light source carried by a first supporting stage;
a second supporting stage having a plurality of reaction assembly receiving positions, each position to receive a reaction assembly, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution;
an imaging sensor positioned to detect fluorescence emitted from a single microarray chip; and
a motion control module to position at least one of the first and second supporting stages to cause a selected microarray chip to receive energy emitted from the light source and to position the imaging sensor to receive fluorescence from that microarray chip.
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Abstract
A multi-channel microarray reader has a light source carried by a first supporting stage, a second supporting stage having a plurality of reaction assembly receiving positions, each position to receive a reaction assembly, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution. The reader also includes an imaging sensor positioned to detect fluorescence emitted from a single microarray chip and a motion control module to position at least one of the first and second supporting stages to cause a selected microarray chip to receive energy emitted from the light source and to position the imaging sensor to receive fluorescence from that microarray chip.
40 Citations
20 Claims
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1. A multi-channel microarray reader, comprising:
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a light source carried by a first supporting stage; a second supporting stage having a plurality of reaction assembly receiving positions, each position to receive a reaction assembly, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution; an imaging sensor positioned to detect fluorescence emitted from a single microarray chip; and a motion control module to position at least one of the first and second supporting stages to cause a selected microarray chip to receive energy emitted from the light source and to position the imaging sensor to receive fluorescence from that microarray chip. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A multi-channel microarray reader, comprising:
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a light source carried by a first supporting stage; a second supporting stage for supporting at least two reaction assemblies, wherein each reaction assembly includes a reaction chamber and an optical substrate to support a microarray chip, and wherein the reaction chamber and the optical substrate encapsulate a buffer solution; an imaging sensor positioned to detect fluorescence emitted from the microarray chip in each reaction assembly; and means for moving at least one of the first stage, the second stage and the imaging sensor, or a combination thereof, to position a selected microarray chip for receiving light emitted from the light source and providing fluorescence to the chip to the imaging sensor. - View Dependent Claims (13, 14)
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15. A method for reading a multi-channel microarray comprising:
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forming a light beam; illuminating a first one of a plurality of microarrays with the light beam to cause fluorescently tagged amplicons associated with the microarray to fluoresce and measuring the strength of the fluorescence; and providing relative movement between the light beam and the plurality of microarrays to illuminate a further one of the plurality of microarrays with the light beam and measuring the strength of the fluorescence. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification