Chronic, Bolus Adminstration Of D-Threo Methylphenidate
First Claim
1. A drug dosage form for the bolus parenteral administration of a methylphenidate drug comprising an injectable composition comprising D-threo-methylphenidate or pharmaceutically acceptable salt thereof in an amount sufficient for daily effectiveness for the treatment of a nervous disorder.
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Abstract
Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
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Citations
25 Claims
- 1. A drug dosage form for the bolus parenteral administration of a methylphenidate drug comprising an injectable composition comprising D-threo-methylphenidate or pharmaceutically acceptable salt thereof in an amount sufficient for daily effectiveness for the treatment of a nervous disorder.
Specification