Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent
First Claim
1. A catheter having a proximal end and an opposite closed off distal end, the catheter comprising:
- a proximal section disposed closest to the proximal end, the proximal section having a substantially uniform outer diameter, the proximal section being formed of a flexible material;
a distal section disposed closest to the distal end;
the distal section being formed of a substantially rigid material;
the distal section formed by a plurality of distal subsections including at least a first distal subsection closest to the proximal end and having a substantially uniform outer diameter and a second distal subsection closest to the distal end and having a substantially uniform outer diameter, wherein the outer diameter of the first distal subsection is greater than the outer diameter of the second distal subsection;
the second distal subsection having a plurality of openings defined radially therein; and
the proximal and distal sections having a lumen defined therethrough extending from the proximal end to the distal end.
1 Assignment
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Accused Products
Abstract
A catheter for delivery of a therapeutic agent directly into a targeted tissue that reduces or substantially prevents reflux and back flow by providing rigidity and strength via a stylet thereby eliminating the need for a guide or delivery sheath during positioning. The catheter has a flexible proximal section and a substantially rigid distal section formed from a plurality of distal subsections. The proximal and distal sections having decreasing outer diameters starting from the proximal end and advancing towards the distal end. The distal subsection closest to the distal end providing an adjustable flow rate via multiple output ports defined radially therein while the distal end itself is closed off.
64 Citations
23 Claims
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1. A catheter having a proximal end and an opposite closed off distal end, the catheter comprising:
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a proximal section disposed closest to the proximal end, the proximal section having a substantially uniform outer diameter, the proximal section being formed of a flexible material; a distal section disposed closest to the distal end;
the distal section being formed of a substantially rigid material;
the distal section formed by a plurality of distal subsections including at least a first distal subsection closest to the proximal end and having a substantially uniform outer diameter and a second distal subsection closest to the distal end and having a substantially uniform outer diameter, wherein the outer diameter of the first distal subsection is greater than the outer diameter of the second distal subsection;
the second distal subsection having a plurality of openings defined radially therein; andthe proximal and distal sections having a lumen defined therethrough extending from the proximal end to the distal end. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for positioning of a catheter to deliver a therapeutic agent to a targeted tissue, the catheter having a proximal end and an opposite closed off distal end;
- the catheter further comprising a proximal section disposed closest to the proximal end, the proximal section having a substantially uniform outer diameter, the proximal section being formed of a flexible material;
the catheter also including a distal section disposed closest to the distal end;
the distal section being formed of a substantially rigid material;
the distal section formed by a plurality of distal subsections including at least a first distal subsection closest to the proximal end and having a substantially uniform outer diameter and a second distal subsection closest to the distal end and having a substantially uniform outer diameter, wherein the outer diameter of the first distal subsection is greater than the outer diameter of the second distal subsection;
the second distal subsection having a plurality of openings defined radially therein; and
the proximal and distal sections having a lumen defined therethrough extending from the proximal end to the distal end, comprising the steps of;inserting a stylet into the lumen, the stylet extending into the lumen at least partially in the distal section. - View Dependent Claims (18, 19, 20, 21, 22, 23)
- the catheter further comprising a proximal section disposed closest to the proximal end, the proximal section having a substantially uniform outer diameter, the proximal section being formed of a flexible material;
Specification