Co-detection of single polypeptide and polynucleotide molecules
First Claim
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1. A method for co-detecting a polynucleotide molecule and a polypeptide molecule contained within one sample comprising:
- (a) moving said polynucleotide molecule and said polypeptide molecule through at least one interrogation volume; and
(b) measuring at least one electromagnetic characteristic of said polynucleotide molecule and measuring at least one electromagnetic characteristic of said polypeptide molecule,wherein said polynucleotide molecule and said polypeptide molecule are co-detected.
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Abstract
The invention relates to a method for co-detecting and distinguishing individual polypeptide and polynucleotide molecules in a single sample analysis. The polypeptide and polynucleotide targets which emit electromagnetic radiation are labeled with probes that emit electromagnetic radiation at the same emission wavelength, are suspended in fluid and moved through an interrogation volume allowing co-detection of low concentrations of individual molecules and discrimination based on characteristics other than emission wavelength.
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Citations
21 Claims
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1. A method for co-detecting a polynucleotide molecule and a polypeptide molecule contained within one sample comprising:
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(a) moving said polynucleotide molecule and said polypeptide molecule through at least one interrogation volume; and (b) measuring at least one electromagnetic characteristic of said polynucleotide molecule and measuring at least one electromagnetic characteristic of said polypeptide molecule, wherein said polynucleotide molecule and said polypeptide molecule are co-detected. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21-91. -91. (canceled)
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