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DIFFERENTIATION OF NON-EMBRYONIC STEM CELLS TO CELLS HAVING A PANCREATIC PHENOTYPE

  • US 20090092586A1
  • Filed: 10/16/2006
  • Published: 04/09/2009
  • Est. Priority Date: 10/14/2005
  • Status: Active Grant
First Claim
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1. A method comprising contacting non-embryonic stem, non-germ, non-embryonic germ cells that can differentiate into at least two of ectodermal, endodermal and mesodermal cell types with a first agent, wherein the first agent is Activin A and a second agent, wherein the second agent inhibits sonic hedgehog (SHH) activity to yield cells having increased expression of Pdx-1.

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