METHOD FOR IMPROVING STOOL CHARACTERISTICS IN INFANTS

• US 20090092590A1
• Filed: 04/14/2008
• Published: 04/09/2009
• Est. Priority Date: 10/08/2007
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: RANGAVAJLA, NAGENDRA, Franco, Joaquin
• Granted Patent: US 10,251,899 B2
• Time in Patent Office: Days
• US Class Current: 424/93.45
• CPC Class Codes: A61K 31/7016 Disaccharides, e.g. lactose, lactulose lactobionic acid A61K31/7032
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61P 1/12 Antidiarrhoeals

Abstract

In accordance with the present invention, a novel method for improving the stool characteristics, reducing the incidence of diarrhea, and firming the stool of a formula-fed infant of a formula-fed infant has been discovered. The method comprises administering to the infant at least one prebiotic and hydrolyzed pectin.

Claims

1. A method for improving the stool characteristics of a formula-fed infant, the method comprising administering to the infant at least one prebiotic and hydrolyzed pectin.

2. The method according to claim 1 wherein the prebiotic is selected from the group consisting of fructo-oligosaccharide, inulin, gluco-oligosaccharide, galacto-oligosaccharide, isomalto-oligosaccharide, xylo-oligosaccharide, soybean oligosaccharides, chito-oligosaccharide, gentio-oligosaccharide, manno-oligosacchaide, lactulose, lactosucrose, raffinose, aribino-oligosaccharide, glucans, siallyl-oligosaccharide, polydextrose, inulin, fuco-oligosaccharide, and mixtures thereof.

3. The method according to claim 1 wherein the amount of prebiotic administered is between about 1.0 g/L and 10.0 g/L, administered daily.

4. The method according to claim 1 wherein the amount of prebiotic administered is between about 2.0 g/L and 8.0 g/L, administered daily.

5. The method according to claim 1 wherein the hydrolyzed pectin is partially hydrolyzed.

6. The method according to claim 1 wherein the amount of hydrolyzed pectin is between about 0.1 g and about 5 g per 100 kcal of total composition.

7. The method according to claim 1 wherein the amount of hydrolyzed pectin is between about 0.25 g to about 1 g per 100 kcal of total composition.

8. The method according to claim 1, additionally comprising the administration of at least one insoluble fiber or non-fermentable fiber.

9. The method according to claim 1, additionally comprising the administration of at least one LCPUFA.

10. The method according to claim 1, wherein the LCPUFA comprises DHA or ARA.

11. The method according to claim 1, wherein the LCPUFA comprises DHA and ARA.

12. The method according to claim 1, additionally comprising the administration of at least one probiotic.

13. The method according to claim 29, wherein the probiotic is selected from the group consisting of Bifidobacteria spp. and Lactobacillus spp.

14. A method for producing firm stool in a formula-fed infant, the method comprising administering to the infant at least one prebiotic and hydrolyzed pectin.

15. A method for reducing the incidence of diarrhea in a formula-fed infant, the method comprising administering to the infant at least one prebiotic and hydrolyzed pectin.

16. The method according to claim 15 wherein the amount of prebiotic administered is between about 1.0 g/L and 10.0 g/L, administered daily.

17. The method according to claim 15 wherein the amount of prebiotic administered is between about 2.0 g/L and 8.0 g/L, administered daily.

18. The method according to claim 15 wherein the amount of hydrolyzed pectin is between about 0.1 g and about 5 g per 100 kcal of total composition.

19. The method according to claim 15 wherein the amount of hydrolyzed pectin is between about 0.25 g to about 1 g per 100 kcal of total composition.

20. The method according to claim 15 wherein the hydrolyzed pectin is partially hydrolyzed.