POLYMER-METAL CHELATOR CONJUGATES AND USES THEREOF
First Claim
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1. A composition comprising at least one D-penicillamine covalently bonded to a biocompatible polymer via a disulfide bond, wherein the disulfide bond comprises the sulfur group of D-penicillamine.
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Abstract
The present invention provides prodrugs comprising a polymer conjugated to a metal chelator via a disulfide bond. For example, D-penicillamine may be conjugated to a polymer (e.g., gelatin, chitosan, polyglutamic acid) via a linker, such as SPDP. Thus, the cellular delivery and pharmacokinetics of D-penicillamine can be substantially improved. Methods for the treatment of cancer using compositions of the present invention are also disclosed.
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34 Claims
- 1. A composition comprising at least one D-penicillamine covalently bonded to a biocompatible polymer via a disulfide bond, wherein the disulfide bond comprises the sulfur group of D-penicillamine.
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