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HUMANIZED ANTIBODY

  • US 20090093002A1
  • Filed: 07/13/2007
  • Published: 04/09/2009
  • Est. Priority Date: 07/14/2006
  • Status: Active Grant
First Claim
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1. A chimeric antibody or a fragment thereof, or a humanized antibody or a fragment thereof, which specifically binds to at least one epitope on the β

  • -amyloid protein wherein the epitope comprises at least two consecutive amino acid residues predominantly involved in binding to the antibody, wherein the at least two consecutive amino, acid residues are -Lys-Leu- embedded within the following core sequence (SEQ ID NO;

         10);

    Xaa1-Xaa2-Lys-Leu-Xaa3 whereinXaa1 is an amino acid selected from the group consisting of His, Asn, Gln Lys, and Arg,Xaa2 is an amino acid selected from the group consisting of Asn and Gln; and

    Xaa3 is an amino acid selected from the group consisting of Ala, Val, Leu, norleucine, Met, Phe, and Ile.

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