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Biosensors for ligand-directed functional selectivity

  • US 20090093011A1
  • Filed: 11/30/2007
  • Published: 04/09/2009
  • Est. Priority Date: 10/05/2007
  • Status: Abandoned Application
First Claim
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1. A method for determining ligand-directed functional selectivity of a receptor of a live-cell, the method comprising:

  • immobilizing a live-cell having a selected receptor on a biosensor;

    contacting the immobilized live-cell with a molecular fragment of a ligand of the receptor;

    contacting the molecular fragment contacted immobilized live-cell with a stimulus; and

    detecting and comparing the stimulus-induced biosensor response of the live-cell in the presence and absence of the molecular fragment.

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