Fragranced Therapeutic Delivery System

• US 20090093440A1
• Filed: 12/20/2006
• Published: 04/09/2009
• Est. Priority Date: 12/20/2005
• Status: Abandoned Application

• Current Assignee: Tremo-Tec GmbH
• Original Assignee: Tremo-Tec GmbH
• Inventors: Murad, Howard
• Application Number:
  US12/086,911
• Publication Number:
  US 20090093440A1
• Time in Patent Office: Days
• US Class Current: 514/55
• CPC Class Codes: A61K 2800/51 Chelating agents
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/355 Quinones
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/678 Tocopherol, i.e. vitamin E
• CPC Class Codes: A61K 8/68 Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
• CPC Class Codes: A61K 8/69 : containing fluorine
• CPC Class Codes: A61K 8/9761 : Cupressaceae [Cypress family], e.g. juniper or cypress
• CPC Class Codes: A61K 8/9767 : Pinaceae [Pine family], e.g. pine or cedar
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 : Liliopsida [monocotyledons]
• CPC Class Codes: A61P 17/00 : Drugs for dermatological disorders
• CPC Class Codes: A61Q 13/00 : Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 : for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/06 : for countering cellulitis
• CPC Class Codes: A61Q 7/00 : Preparations for affecting hair growth
• CPC Class Codes: A61Q 9/04 : Depilatories

Abstract

The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase; (ii) an aqueous phase; (iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition; (iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12-C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12-C24 fatty alcohol esterified to a carboxyl group; (v) a non-ionic emulsifier having an HLB of from about 7 to about 10; (vi) a fragrance composition; and (vii) at least one skin-supporting or dermatopharmaceutically active agent.

Claims

1. An oil-in-water emulsion topical delivery system comprising (i) an oil phase;

(ii) an aqueous phase;

(iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition;

(iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C₁₂-C₂₄ fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C₁₂-C₂₄ fatty alcohol esterified to a carboxyl group;

(v) a non-ionic emulsifier having an HLB of from about 7 to about 10;

(vi) a fragrance composition; and

(vii) at least one skin-supporting or dermatopharmaceutically active agent.

2. The topical delivery system of claim 1 where the phenoxyethanol is present at a concentration of from about 2.3% to about 2.7%.

3. The topical delivery system of claim 1 further comprising hydrogen peroxide.

4. The topical delivery system of claim 3 where the hydrogen peroxide is present at a concentration of less than about 3% based on the total weight of the composition.

5. The topical delivery system of claim 4 further comprising a hydrogen peroxide stabilizer selected from the group consisting of amphoteric surfactants, dimethyl amine oxides, chelating agents, tricarboxylic α

-hydroxy acids.

6. The topical delivery system of claim 5 where the chelating agent is selected from the group consisting of mono- di-, tri- and tetra-acetic acid derivatives of ethylene diamine.

7. The topical delivery system of claim 6 where the chelating agent is a tetra-acetic acid derivative of ethylene diamine.

8. The topical delivery system of claim 6 where the chelating agent is present at concentration of from about 0.05% to about 0.1% based on the total weight of the composition.

9. The topical delivery system of claim 5 where the tricarboxylic hydroxyacid is 2-hydroxy-1,2,3-propanetricarboxylic acid.

10. The topical delivery system of claim 1 wherein the pH of the topical delivery system is from bout 1.5 to about 2.5 pH units lower than the average pH of the acid mantle of the skin.

12. The topical delivery system of claim 1 further comprising a hydrophilic hydroxycarboxylic acid.

13. The topical delivery system of claim 12 where the hydrophilic hydroxycarboxylic acid has a hydroxyl group covalently bonded to the alpha carbon of a carboxylic acid.

14. The topical delivery system of claim 12 where the hydrophilic hydroxycarboxylic acid is selected from the group consisting of 2-hydroxyethanoic acid;

2-hydroxypropanoic acid;

2-hydroxy-2-phenylethanoic acid;

2-hydroxy-1,4-butanedioc acid;

2,3-dihydroxy-1,4-butanedioc acid;

2-hydoxy-,1,2,3-propanetricarboxylic acid.

15. The topical delivery system of claim 12 where the hydrophilic hydroxycarboxylic acid conforms to the formula HOCH₂[CH(OH)]_nC(═

O)OH, where n is an integer from 1 to 10.

16. The topical delivery system of claim 12 wherein the pH of the topical delivery system is from bout 1.5 to about 2.5 pH units lower than the average pH of the acid mantle of the skin.

22. The topical delivery system of claim 1 where the hydrophobic hydroxycarboxylic acid is orthohydroxybenzoic acid.

23. The topical delivery system of claim 22 where the hydrophobic hydroxycarboxylic acid is present at a concentration of at least about 0.5%.

28. The topical delivery system of claim 1 wherein the skin-supporting or dermatopharmaceutically active ingredient is selected from the group consisting of agents that reduce the appearance of signs of aging, including fine lines and wrinkles, age spots;

amino acids;

essential fatty acids;

glycosaminoglycans;

inhibitors of enzymes that breakdown collagen or elastin;

stimulators of collagen or elastin synthesis;

antioxidant agents;

anti-inflammatory agents;

anti-erythemal agents;

anti-acne agents;

sebum modulators;

exfoliating agents;

anti-seborrheic agents;

antimicrobial agents;

anthelmintic agents;

skin bleaching and skin lightening agents;

anti-cellulite agents;

agents that block or absorb ultraviolet radiation and protect the skin from photodamage;

agents that promote hair growth;

agents that stop or reduce hair loss;

hair removal agents;

anti-dandruff agents;

anesthetic agents;

analgesics;

tranquilizers;

sedatives;

muscle relaxants;

vasodilators;

vasoconstrictors;

nitric oxide releasing substances;

immunomodulators;

peptides, lipopeptides, and derivatives thereof;

hormones;

astringents;

moisturizers;

ceramides;

hyaluronan and its derivatives;

alpha-lipoid acid;

vitamins;

minerals;

an essential oil; and

combinations thereof.

102. The topical delivery system of claim 1 further comprising a non-ionic co-emulsifier having an HLB of from about 8 to about 11.

105. The topical delivery system of claim 1 wherein the fragrance component is an undiluted essential oil.

108. The topical delivery system of claim 105 wherein the undiluted essential oil is present at a concentration of at least about 0.1%.

111. A method for treating a pathophysiologic condition selected from the group consisting of dermatologic conditions, inflammatory conditions, immuno-suppressed conditions, infectious conditions, and disambiguation comprising administering a therapeutically-effective amount of the composition of claim 1 to a person in need thereof.

11. (canceled)

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