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Diacylglycerol Acyltransferase Inhibitors

  • US 20090093497A1
  • Filed: 05/01/2008
  • Published: 04/09/2009
  • Est. Priority Date: 05/22/2007
  • Status: Active Grant
First Claim
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1. A compound of formula (I):

  • wherein;

    R1 is phenyl or 5- or 6-membered heteroaryl, said phenyl and heteroaryl being unsubstituted or substituted with halogen, lower alkyl, alkoxy or O—

    CF3;

    R2 is halogen, lower alkyl, haloloweralkyl or alkoxy;

    R3 is -lower alkyl,alkoxy,hydroxy,amine,lower alkyl amine,haloloweralkyl,lower alkoxy,lower alkenyloxy,cycloloweralkyl, unsubstituted or substituted with one to four substituents from loweralkyl, hydroxy, halogen, —

    C(O)OH, —

    C(O)O-lower alkyl or —

    C(O)O-lower alkyl-phenyl,5- or 6-membered heterocycloalkyl, unsubstituted or substituted, with one to four substituents from lower alkyl, hydroxy, halogen, —

    SO2-loweralkyl, —

    C(O)OH, —

    C(O)O-lower alkyl or —

    C(O)O-lower alkyl-phenyl,5- or 6-membered aryl, unsubstituted or substituted with one to four substituents fromlower alkyl, hydroxy, halogen, —

    C(O)OH, —

    C(O)O-lower alkyl or —

    C(O)O-lower alkyl-phenyl,5- or 6-membered heteroaryl, unsubstituted or substituted with one to four substituents from lower alkyl, hydroxy, halogen, —

    C(O)OH, C(O)O-lower alkyl or —

    C(O)O-lower alkyl-phenyl,(CH2)nC(O)OH,CH2C(lower alkyl)2C(O)OH,CH2(cycloalkyl)C(O)OH,(cycloalkyl)C(O)OH,CH2C(CH3)3,(CH2)n-cycloalkyl,cycloalkenyl,bicycloalkenyl-C(O)OH,(CH2)n

    O-alkyl,O—

    C(═

    C)-loweralkyl,O—

    (CH2)n-phenyl,NSO2-loweralkyl,NSO2-cycloalkyl,NSO2-aryl,N-lower alkyl,N-cycloalkyl, said cycloalkyl being unsubstituted or substituted with -C(O)OH,N-heterocycloalkyl,N-aryl,N—

    (CH2)n-aryl,N-heteroaryl, said heteroaryl being unsubstituted or substituted with alkyl,N—

    CH(lower alkyl)C(O)OH,N—

    (cycloalkyl)C(O)OH,N—

    CH(lower alkyl)C(O)O-lower alkyl, orphenyl-C(O)OH;

    X is 5- or 6-membered aryl or 5- or 6-membered heteroaryl, said aryl or heteroaryl being unsubstituted or substituted with lower alkyl, halogen or cyano;

    Y is phenyl, heteroaryl, cycloloweralkyl, or 5- or 6-membered heterocycloalkyl, —

    N(CH2)n)N—

    , said phenyl, cycloloweralkyl or heterocycloalkyl being unsubstituted or substituted with lower alkyl, halogen or cyano;

    n is 1, 2 or 3, or pharmaceutically acceptable salts thereof.

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