CROSSED-LINKED HYALURONIC ACID AND COLLAGEN AND USES THEREOF
First Claim
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1. A method for preparing an implant, comprising:
- contacting hyaluronic acid (HA) with a cross-linker to allow cross-linking of the HA by the cross-linker, thereby forming a first composition;
contacting the first composition with collagen to allow cross-linking of the collagen by the cross-linker, thereby forming a second composition; and
contacting the second composition with a HA solution to allow cross-linking of the HA in the solution by the cross-linker, thereby producing an implant.
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Abstract
The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.
195 Citations
35 Claims
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1. A method for preparing an implant, comprising:
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contacting hyaluronic acid (HA) with a cross-linker to allow cross-linking of the HA by the cross-linker, thereby forming a first composition; contacting the first composition with collagen to allow cross-linking of the collagen by the cross-linker, thereby forming a second composition; and contacting the second composition with a HA solution to allow cross-linking of the HA in the solution by the cross-linker, thereby producing an implant. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. An implant, comprising:
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a core of HA cross-linked by a cross-linker; a middle layer of collagen surrounding and cross-linked by the cross-linker to the core; and an outer layer of HA surrounding and cross-linked by the cross-linker to the collagen layer. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification