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DRUG ELUTING STENTS WITH PROLONGED LOCAL ELUTION PROFILES WITH HIGH LOCAL CONCENTRATIONS AND LOW SYSTEMIC CONCENTRATIONS

  • US 20090093875A1
  • Filed: 04/30/2008
  • Published: 04/09/2009
  • Est. Priority Date: 05/01/2007
  • Status: Abandoned Application
First Claim
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1. A drug eluting stent comprising:

  • a stent body;

    a polymeric coating disposed on the stent body;

    a drug disposed in the polymeric coating, said drug being present at an amount greater than or equal to about 150 ug/cm2; and

    wherein the polymeric coating and drug cooperate to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.

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