TRANSDERMAL, ALCOHOL-FREE, PHARMACEUTICAL COMPOSITIONS
First Claim
Patent Images
1. An alcohol-free composition comprising:
- an effective amount of one or more physiologically active agents;
an effective amount of one or more dermal penetration enhancers selected from the group consisting of ethers of diethylene glycol and ester sunscreens; and
one or more non-volatile liquids in an alcohol-free composition.
14 Assignments
0 Petitions
Accused Products
Abstract
An alcohol-free, transdermal drug delivery composition administered via a metered spray drug delivery device is described herein. The non-occlusive transdermal drug delivery composition includes a therapeutically effective amount of at least one physiologically active agent or prodrug thereof, an effective amount of at least one dermal penetration enhancer; and at least one non-volatile liquid. The transdermal drug delivery composition is administered to a dermal or mucosal surface of an animal needing the same using a metered spray device capable of delivering a fine spray of substantially uniform particle size to minimize the required drying time therefor.
-
Citations
65 Claims
-
1. An alcohol-free composition comprising:
-
an effective amount of one or more physiologically active agents; an effective amount of one or more dermal penetration enhancers selected from the group consisting of ethers of diethylene glycol and ester sunscreens; and
one or more non-volatile liquids in an alcohol-free composition. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 53, 54, 55)
-
-
2. A drug delivery device comprising:
-
an effective amount of one or more physiologically active agents; an effective amount of one or more dermal penetration enhancers; and a non-volatile liquid in an alcohol-free composition contained within a valve-actuated metered spray drug delivery device. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
-
34. A method of making an alcohol-free drug delivery composition comprising:
-
combining an effective amount of one or more physiologically active agents;
an effective amount of one or more dermal penetration enhancers selected from the group consisting of ethers of diethylene glycol and ester sunscreens; and
one or more non-volatile liquids in an alcohol-free composition. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
-
-
35. A method of administering an alcohol-free drug delivery composition comprising:
-
spraying an effective amount of one or more physiologically active agents;
an effective amount of one or more dermal penetration enhancers selected from the group consisting of ethers of diethylene glycol and ester sunscreens; and
one or more non-volatile liquids in an alcohol-free composition onto a dermal or mucosal surface. - View Dependent Claims (49, 50, 51, 52)
-
-
56. A non-occlusive, transdermal drug delivery composition which comprises:
-
(i) a therapeutically effective amount of at least one physiologically active agent; (ii) at least one dermal penetration enhancer, which is present in an amount of from 10 to 10,000 wt % based on the weight of the active agent; (iii) at least one non-volatile liquid present in an amount to act as a vehicle for the active agent and penetration enhancer;
wherein;the dermal penetration enhancer (A) is adapted to transport the physiologically active agent across a dermal or mucosal surface of an animal, when the non-volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent within said surface or membrane, and (B) is tolerated by the dermal or mucosal surface of the animal; and
,after administration of the composition to an area of the dermal or mucosal surface, the area becomes dry within 4 minutes of application. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65)
-
Specification