Composite Bone Material and Method of Making and Using Same

• US 20090098092A1
• Filed: 08/11/2008
• Published: 04/16/2009
• Est. Priority Date: 08/11/2007
• Status: Abandoned Application

• Current Assignee: Thomas L. Meredith
• Original Assignee: Thomas L. Meredith
• Inventors: Meredith, Thomas L.
• Application Number:
  US12/189,755
• Publication Number:
  US 20090098092A1
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders

Abstract

Bone composite implants and the method of constructing bone composite implants are disclosed which may be used in the repair, replacement, and/or augmentation of various portions of animal or human skeletal systems. Furthermore, the bone composite implants of the present invention may be considered load-bearing implants which are incorporated into the skeletal structure of the patient.

Claims

1. A method of forming a bone composite with a growth accelerator, comprising:

a) providing ground bone tissue;

b) molding the ground bone tissue into a bone composite; and

c) adding a growth accelerator to the bone composite to form a bone composite with a growth accelerator.

2. The method of claim 1 further comprising obtaining bone tissue and grinding the bone tissue to form ground bone tissue prior to step a).

3. The method of claim 1 wherein step c) further comprises adding the growth accelerator with a carrier to the bone composite.

4. The method of claim 3 wherein the carrier comprises a binder.

5. The method of claim 4 wherein the binder comprises cyanoacrylate.

6. The method of claim 1 wherein the growth accelerator comprises at least one transforming growth factor.

7. The method of claim 1 wherein the growth accelerator comprises at least one bone morphogenetic protein.

8. The method of claim 7 wherein the bone morphogenetic protein is selected from the group consisting of BMP-2, BMP-3, BMP-4, BMP-7, BMP-8a and combinations thereof.

9. The method of claim 1 wherein the growth accelerator comprises one or more hormones.

10. The method of claim 9 wherein the one or more hormones comprise a synthetic hormone.

11. The method of claim 9 wherein the one or more hormones comprise recombinantly created hormones.

12. The method of claim 9 wherein the one or more hormones comprise amylin.

13. The method of claim 9 wherein the one or more hormones comprise adrenonedullin.

14. The method of claim 1 wherein the growth accelerator comprises a parathyroid hormone-affecting compound.

15. A bone composite, comprising:

ground bone tissue including cortical bone tissue;

a growth accelerator applied to the ground bone tissue to increase bone fusion; and

a binder applied to the ground bone tissue to provide coherency to the bone composite.

16. The composite of claim 15 wherein the growth accelerator comprise one or more transforming growth factors.

17. The composite of claim 15 wherein the growth accelerator comprises one or more bone morphogenetic proteins.

18. The composite of claim 15 wherein the growth accelerator comprises one or more hormones.

19. The composite of claim 18 wherein the one or more hormones comprise synthetic hormones.

20. The composite of claim 18 wherein the one or more hormones comprise calcitonin.

21. The composite of claim 18 wherein the one or more hormones comprise parathyroid hormone.

22. The composite of claim 18 wherein the one or more hormones comprise amylin.

23. The composite of claim 18 wherein the one or more hormones comprise adrenonedullin.

24. The composite of claim 15 wherein the growth accelerator comprises a parathyroid-affecting compound.

25. The composite of claim 15 wherein the growth accelerator comprises a calcitonin-affecting compound.

26. The composite of claim 15 wherein the binder comprises a cyanoacrylate binder.

27. The composite of claim 15 further comprising strengthening elements dispersed within the composition.

28. The composition of claim 27 wherein the strengthening elements have a greater length than width.

29. The composition of claim 28 wherein the strengthening elements comprise fibers.

30. A method of implanting a bone composite with a growth accelerator into a mammal, comprising:

a) providing ground bone tissue, a growth accelerator and a binder;

b) mixing the bone tissue, the growth accelerator, and the binder to form a bone composite with a growth accelerator;

c) inserting the bone composite with the growth accelerator into the mammal;

d) setting the binder of the bone composite with the growth accelerator to provide coherency to the composite.

31. The method of claim 30 wherein the binder comprises a cyanoacrylate binder.

32. The method of claim 31 wherein in step d) the setting of the binder comprises polymerization of the cyanoacrylate binder by at least 50% in less than about 30 minutes after being inserted into the mammal.