METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA MODULATION OF MEGALIN ACTIVITY
First Claim
1. A method for treating an ophthalmic condition in an eye of a mammal comprising,administering to the mammal an effective amount of an agent that modulates the activity of a member of the LDL receptor gene family in the retina and/or retinal pigment epithelium cells in the eye of the mammal.
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Accused Products
Abstract
Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. Provided are methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
24 Citations
25 Claims
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1. A method for treating an ophthalmic condition in an eye of a mammal comprising,
administering to the mammal an effective amount of an agent that modulates the activity of a member of the LDL receptor gene family in the retina and/or retinal pigment epithelium cells in the eye of the mammal.
Specification