METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM
First Claim
1. A computer implemented method for screening a subject for disorders of glucose metabolism, comprising steps of:
- measuring a glucose concentration profile using a glucose concentration analyzer, said glucose concentration profile comprising a plurality of blood glucose concentrations from at least after a glucose or meal challenge;
using a pattern recognition system to generate a screening factor, wherein said screening factor comprises a mathematical representation of at least a plurality of glucose concentrations within said glucose concentration profile, wherein said screening factor is uniquely associated with a state of glucose metabolism disorder, wherein said state of glucose metabolism disorder comprises a chronic condition, wherein said state of glucose metabolism disorder comprises a classification of any of;
a diabetic condition of diabetes mellitus, anda pre-diabetic condition of diabetes mellitus; and
classifying the subject into one of said states of glucose metabolism disorder based on evaluation of said screening factor, wherein said screening factor comprises a representation of said glucose concentration profile; and
outputting said one of said states of glucose metabolism disorder to a display;
wherein said plurality of blood glucose concentrations comprises a time series.
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Abstract
A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject'"'"'s glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
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Citations
14 Claims
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1. A computer implemented method for screening a subject for disorders of glucose metabolism, comprising steps of:
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measuring a glucose concentration profile using a glucose concentration analyzer, said glucose concentration profile comprising a plurality of blood glucose concentrations from at least after a glucose or meal challenge; using a pattern recognition system to generate a screening factor, wherein said screening factor comprises a mathematical representation of at least a plurality of glucose concentrations within said glucose concentration profile, wherein said screening factor is uniquely associated with a state of glucose metabolism disorder, wherein said state of glucose metabolism disorder comprises a chronic condition, wherein said state of glucose metabolism disorder comprises a classification of any of; a diabetic condition of diabetes mellitus, and a pre-diabetic condition of diabetes mellitus; and classifying the subject into one of said states of glucose metabolism disorder based on evaluation of said screening factor, wherein said screening factor comprises a representation of said glucose concentration profile; and outputting said one of said states of glucose metabolism disorder to a display; wherein said plurality of blood glucose concentrations comprises a time series. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A computer implemented method for screening a subject for disorders of glucose metabolism, comprising steps of:
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measuring a glucose concentration profile using a glucose concentration analyzer, said glucose concentration profile comprising a plurality of blood glucose concentrations from at least after a glucose or meal challenge; generating a screening factor, wherein said screening factor comprises a mathematical representation of at least a plurality of glucose concentrations within said glucose concentration profile, wherein said screening factor is uniquely associated with a state of glucose metabolism disorder, wherein said state of glucose metabolism disorder comprises a chronic condition, wherein said state of glucose metabolism disorder comprises a classification of any of; a diabetic condition of diabetes mellitus, and a pre-diabetic condition of diabetes mellitus; and classifying the subject into one of said states of glucose metabolism disorder based on evaluation of said screening factor; and outputting said one of said states of glucose metabolism disorder to a display, wherein said screening factor comprises the result of a supervised classification, wherein said supervised classification defines a class of said screening factor through known differences in data, wherein data comprises said glucose concentration profile.
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Specification