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Heterocyclic inhibitors of necroptosis

  • US 20090099242A1
  • Filed: 08/15/2008
  • Published: 04/16/2009
  • Est. Priority Date: 08/15/2007
  • Status: Abandoned Application
First Claim
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1. A compound having a structure according to Formula (I) whereinX1 and X2 are, independently, N or CR4;

  • X3 is selected from O, S, NR5, or —

    (CR5)2;

    Y is selected from C(O) or CH2; and

    Z is (CR6R7)n,R1 is selected from H, halogen, optionally substituted C1-6 lower alkyl, or optionally substituted C1-6 cycloalkyl, or optionally substituted aryl;

    R2 is selected from H or optionally substituted C1-6 lower alkyl;

    R3 is optionally substituted aryl;

    each R4 is selected from H, halogen, carboxamido, nitro, cyano, optionally substituted lower C1-6 alkyl, or optionally substituted aryl;

    R5 is selected from H, halogen, optionally substituted lower C1-6 alkyl, or optionally substituted aryl;

    each R6 and R7 is, independently, selected from H or optionally substituted C1-6 lower alkyl; and

    n is 0, 1, 2, or 3;

    wherein when X1 and X2 are N, X3 is S, Y, is C(O), Z is CH2, R2 is H, and R3 is 2-chloro-6-fluoro-phenyl, R1 is not methyl;

    or any pharmaceutically acceptable salt or solvate thereof, or stereoisomer thereof.

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