INTELLIGENT SEQUENTIAL ILLUMINATING DEVICE FOR PHOTODYNAMIC THERAPY

• US 20090099499A1
• Filed: 10/16/2008
• Published: 04/16/2009
• Est. Priority Date: 04/19/2006
• Status: Abandoned Application

• Current Assignee: Ruđjer Bošković Institute
• Original Assignee: Ruđjer Bošković Institute
• Inventors: Loncaric, Martin, Radman, Anton, Agatic, Nenad, Persin, Antun, Tisaj, Kreso, Roudnicky, Dunja Soldo, Zorc, Hrvoje, Stanisic, Vitomir
• Application Number:
  US12/252,785
• Publication Number:
  US 20090099499A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61N 2005/0629 Sequential activation of light sources
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

Intelligent sequential illuminating device for photodynamic therapy of surface tumors that comprises: the module for illumination and detection, module for signal processing and control and module for power supply, of which the module for illumination and detection consists of the violet light emitting diodes (405) and the red light emitting diodes (640), where the violet light emitting diodes serve for fluorescence excitation of the photo reactive agent and the red light emitting diodes have twofold purpose: for emission and therapeutic red light and for detection of the red fluorescent light caused by illumination of the violet light emitting diodes. The module for signal processing and control manages a work of the light emitting diodes so that the violet light emitting diodes are activated into the determined sequences during which the red light emitting diodes measure the level of ppix fluorescence. Depending on the measured fluorescent intensity, the red light emitting diodes are activated between the pulses of the violet light emitting diodes.

Claims

1. Intelligent sequential illuminating device comprising a module for illumination and detection, module for signal processing and control and module for power supply, characterized in that the said module for illumination and detection consists of two kinds of matrices of light emitting diodes:

the matrix with the light emitting diodes of short wavelength serving to excite the fluorescence of photoreactive agent and the matrix with the led emitting diodes of longer wavelength where the said matrix with the light emitting diodes of longer wavelength has twofold purpose;

the first purpose is to provide the detection of fluorescent light of the photoreactive agent excited by the said matrix with the light emitting diodes of shorter wavelength and the second purpose is to provide the optimal excitation of the photoreactive agent in the sense that the said module with the matrix of the shorter wavelength and the said module with the matrix of the longer wavelength are sequentially activated with the different activation times of the said matrix with the longer wavelength according to the measured fluorescence intensity levels of the photoreactive agent measured by the same matrix with the light emitting diodes of the longer wavelength whereby the said intensity level depends on the photoreactive agent concentration.

2. The illuminator according to claim 1, characterized in that, the matrix of the red light emitting diodes comprises an array of the red light emitting diodes which detects at the wavelength of the maximum fluorescence of the photo reactive agent.

3. The illuminator according to claim 1, characterized in that, the red light emitting diode emit at the maximum wavelength that is acceptable for absorption of the photo reactive agent, wherewith it is enabled the light emission and detection of the fluorescence of the photo reactive agent.

4. The illuminator according to claim 1, characterized in that, the matrix of the light emitting diodes comprises an array of the light emitting diodes with the resistors emitting in the wave length needed to excite the fluorescence of the photo reactive agent.

5. The illuminator according to claim 1, characterized in that, the matrix of the violet light emitting diodes and the red light emitting diodes together with the module for analog signal processing and the module for control estimate a concentration level of the photoreactive agent in the period of the photoreactive agent accumulation and in relation to the fluorescence intensity an optimum time of incubation.

6. The illuminator according to claim 1, characterized in that, the red light emitting diodes stop illuminating by means of the matrix of the violet light emitting diodes, and the matrix of the red light emitting diodes, and the system of the microprocessor logic module, when the fluorescent signal caused by means of the violet light emitting diodes drops below the determined level, i.e. switches on the matrix array of the red light emitting diodes when the concentration of the photo reactive agent has recurred, i.e. until the concentration of the photo reactive agent drops at the minimum before determined value.