DEVICE FOR DRUG ADMINISTRATION AND/OR MONITORING THE STATUS OF A PATIENT

• US 20090099508A1
• Filed: 05/02/2007
• Published: 04/16/2009
• Est. Priority Date: 05/11/2006
• Status: Active Grant

• Current Assignee: Biora Therapeutics Incorporated
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Krijnsen, Henrike, Van Bruggen, Michel, Langereis, Geert, Iordanov, Ventzeslav
• Granted Patent: US 9,386,925 B2
• Time in Patent Office: Days
• US Class Current: 604/66
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

The invention relates to a device for drug administration and/or monitoring the status of a patient, the device comprising a first and a second measuring means, and the time for using the second measuring means being set in accordance with the data of the first measuring means.

Claims

1. A device for drug administration and/or monitoring the status of a patient comprising

a) a measuring means, which measures at least one first body parameter of a patient for at least 1 measuring cycle and at least 1 monitoring cycle,

b) a normalizing means, which generates a normalized curve for each of the measured body parameter(s) of the patient from the data obtained in the measuring cycles and adjusts the data obtained in the at least one monitoring cycle to normalized data based on the normalized curve to obtain normalized monitoring data,

c) a second measuring means which measures at least one second body parameter in response to the output of the normalizing means of the at least one first body parameter,

d) optionally, a comparison means which compares the second body parameter data with pre-stored comparison data,

e) optionally, a drug delivery device which comprises a drug release means, which starts a drug release program based upon the comparison between the second body parameter data and the pre-stored comparison data.

2. The device according to claim 1, wherein the at least one first body parameter includes body temperature, core body temperature, skin surface temperature, activity (body or brain), heart rate, melatonin level, triacylglycerol level, cortisol level.

3. The device according to claim 1 or 2, wherein the at least one second body parameter is blood pressure.

4. The device according to any of the claims 1 or 3, wherein the second measuring means starts measuring when during the at least 1 monitoring cycle a change in the normalized monitoring data is observed of ≧

40%/hour (on the normalized scale) over ≧

1 hours.

5. The device according to any of the claims 1 to 4, wherein the second measuring means starts measuring when during the at least 1 monitoring cycle a drop in the normalized monitoring data is observed of ≧

40%/hour (on the normalized scale) over ≧

1 hours and/or the normalized data falls under (the absolute value of) 50%.

6. The device according to any of the claims 1 to 5, wherein the second measuring means is stopped when during the at least 1 monitoring cycle the normalized monitoring data deviates from the normalized 0%-point of the normalized curve by a threshold value of ≦

5% and is increasing.

7. The device according to any of the claims 1 to 6, wherein the second measuring means is stopped when during the at least 1 monitoring cycle an average increase in the normalized monitoring data is observed of ≧

40%/hour (on the normalized scale) over ≧

1 hours and/or the normalized data rises above (the absolute value of) 40%.

8. The device according to any of the claims 1 to 7, wherein the device furthermore comprises a fitting means which generates a fitting curve of the data of the second body parameter.

10. A system incorporating a device according to any of the claims 1 to 8 or using the method of claim 9 and being used in one or more of the following applications:

medical devices for the administration of drugs

medical devices for treatment of chronic diseases

9. A method for the controlled release of drugs and/or monitoring the status of a patient, comprising the steps of

a) measuring at least one body parameter of the patient for at least 3 measuring cycles and at least 1 monitoring cycle,

b) generating a normalized curve for each of the measured body parameter(s) of the patient from the data obtained in the measuring cycles and adjusting the data obtained in the at least one monitoring cycle to normalized data based on the normalized curve to obtain normalized monitoring data,

c) starting and/or stopping a measurement of at least one second body parameter in response to the output of the normalizing means of the at least one first body parameter,

d) optionally, generating a fitting curve of the data of the at least one second body parameter,

e) optionally, starting a drug release based upon the comparison of the data of step c) and/or d) with a comparison means.