SYSTEMS AND METHODS FOR IMPLEMENTING HEART GEOMETRICAL MEASUREMENTS
First Claim
1. A method of identifying the source of reentrant ventricular tachycardia in a patient, said method comprising:
- a) obtaining one or more images of the region of the patient'"'"'s heart;
b) identifying a border zone (BZ);
c) calculating the thickness of the BZ;
d) constructing a three-dimensional thickness map by measuring the thickness of said border zone at multiple points so that a sufficient spatial resolution is obtained, and determining a local spatial gradient (Δ
T) of said thickness over two or more locations in said BZ; and
e) using said thickness and Δ
T to determine the reentry isthmus location and one or more candidate ablation sites.
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Accused Products
Abstract
In some embodiments, the disclosed subject matter provides a method of identifying the source of arrhythmia, e.g. reentrant ventricular tachycardia, in a patient. In other embodiments, the disclosed subject matter provides a method for treating or preventing reentrant ventricular tachycardia in a patient. In still other embodiments, the disclosed subject matter provides systems for identifying the location of a candidate ablation site in a patient. In some embodiments, the patient has suffered from a myocardial infarction or has undergone structural remodeling of the heart caused by, e.g., cardiac fibrosis or the presence of dense trebeculation, resulting in nonviable areas with border zones (BZ).
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Citations
20 Claims
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1. A method of identifying the source of reentrant ventricular tachycardia in a patient, said method comprising:
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a) obtaining one or more images of the region of the patient'"'"'s heart; b) identifying a border zone (BZ); c) calculating the thickness of the BZ; d) constructing a three-dimensional thickness map by measuring the thickness of said border zone at multiple points so that a sufficient spatial resolution is obtained, and determining a local spatial gradient (Δ
T) of said thickness over two or more locations in said BZ; ande) using said thickness and Δ
T to determine the reentry isthmus location and one or more candidate ablation sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for treating, preventing, and/or inhibiting postinfarction reentrant ventricular tachycardia in a patient, said method comprising:
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a) obtaining one or more images of the patient'"'"'s heart; b) identifying a border zone (BZ); c) calculating the thickness of the BZ; d) constructing a three-dimensional thickness map by measuring the thickness of said border zone at multiple points so that a sufficient spatial resolution is obtained, and determining a local spatial gradient (Δ
T) of said thickness over two or more locations in said BZ;e) using said thickness and Δ
T to determine the reentry isthmus location and one or more candidate ablation sites; andf) performing ablation of said one or more candidate ablation sites. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A system for identifying the location of a candidate ablation site in a patient, the system comprising:
a) a processor, image acquisition means for obtaining images of a patient'"'"'s heart operatively coupled to the processor, and a memory operatively coupled to the processor, the memory storing program instructions that when executed by the processor, cause said processor to utilize said image acquisition means for obtaining images to; obtain images of a patient'"'"'s heart; display each image on a screen; measure a thickness of a border zone; determine a local spatial gradient (Δ
T) of said thickness over two or more locations in said border zones;plot said thickness and thickness gradient values on three-dimensional maps; and locate estimated positions of reentrant circuits and actual conduction block during reentrant ventricular tachycardia. - View Dependent Claims (19, 20)
Specification